Cixian Cancer Institute, Handan, 056500, China.
Cancer Institute, The Fourth Hospital of Hebei Medical University/The Tumor Hospital of Hebei Province, Shijiazhuang, 050011, China.
Cancer Med. 2018 Apr;7(4):1537-1545. doi: 10.1002/cam4.1416. Epub 2018 Mar 13.
Cixian is one of the high-risk areas for upper gastrointestinal cancer in China and the world. From 2005, comprehensive population-based screening for upper gastrointestinal cancers has been conducted in Cixian. The aim of this study was to investigate population-based cancer survival from 2003 to 2013 and to explore the effect of screening on upper gastrointestinal cancer survival in Cixian. Observed survival was estimated using the life table method. The expected survival from the general population was calculated using all-cause mortality data from the population of Cixian with the EdererII method. Cixian cancer registry, with a total coverage of 6.88 million person years, recorded 19,628 cancer patients diagnosed during 2003-2013. In Cixian, from 2003 to 2013, there were 19,628 newly cancer cases and 13,984 cancer deaths, with an incidence rate of 285.37/100,000 and mortality rate of 203.31/100,000. The overall five-year relative cancer survival for patients diagnosed in Cixian in 2003-2013 was 22.53%. The relative survival for all cancers combined in Cixian had an overall upward trend from 2003 to 2013. Among upper gastrointestinal cancer in Cixian, the five-year relative survival for cardia gastric cancer was highest at 30.42%, followed by oesophageal cancer at 25.37% and noncardia gastric cancer at 18.93%. In 2013, the five-year relative survival for oesophageal cancer, cardia gastric cancer, and noncardia gastric cancer patients aged 45-69 years was 39.97% (95% CI: 34.52-45.43%), 51.74% (95% CI: 42.09-60.86%), and 37.43% (95% CI: 26.93-48.17%), respectively, the absolute values increasing 14.11%, 16.71%, and 14.92% compared with that in 2003. There is an increasing trend in overall survival for upper gastrointestinal cancer with early screening and treatment of cancer in Cixian.
磁县是中国乃至世界上高发的上消化道癌地区之一。自 2005 年以来，在磁县开展了以上消化道癌为重点的全人群筛查工作。本研究旨在调查 2003-2013 年的人群癌症生存状况，并探讨筛查对磁县上消化道癌生存的影响。采用寿命表法估计观察生存率，应用 EdererII 法计算全死因死亡率的一般人群预期生存率。磁县癌症登记处共覆盖 688 万人年，记录了 2003-2013 年期间诊断的 19628 例癌症患者。在磁县，2003-2013 年期间共有 19628 例新发癌症病例和 13984 例癌症死亡病例，发病率为 285.37/10 万，死亡率为 203.31/10 万。2003-2013 年在磁县诊断的患者的总体 5 年相对癌症生存率为 22.53%。2003-2013 年期间，磁县所有癌症的相对生存率呈总体上升趋势。在磁县的上消化道癌中，贲门胃癌的 5 年相对生存率最高，为 30.42%，其次是食管癌，为 25.37%，非贲门胃癌为 18.93%。2013 年，45-69 岁的食管癌、贲门胃癌和非贲门胃癌患者的 5 年相对生存率分别为 39.97%（95%CI：34.52-45.43%）、51.74%（95%CI：42.09-60.86%）和 37.43%（95%CI：26.93-48.17%），与 2003 年相比，绝对值分别增加了 14.11%、16.71%和 14.92%。随着磁县上消化道癌的早期筛查和治疗，总体生存率呈上升趋势。
