a Gazi Universitesi Saglik Bilimleri Fakultesi, Nutrition and Dietetics , Ankara , Turkey.
J Am Coll Nutr. 2018 Aug;37(6):546-551. doi: 10.1080/07315724.2018.1431160. Epub 2018 Mar 13.
Nonclassical target organs recently defined for vitamin D, a major regulator of calcium phosphorus homeostasis and bone health, include reproductive ones. This compilation study focuses on the potential effects of vitamin D on female reproductive functions. Vitamin D receptor enzymes that metabolize vitamin D are expressed in both central and peripheral reproductive organs. Most studies suggest that vitamin D may be directly or indirectly related to gonadal functions. Vitamin D's effects on reproductive functions may be indirectly related to diseases such as polycystic ovary syndrome (PCOS), uterine leiomyomas, and endometriosis. In case of vitamin D deficiency during infertility treatment, vitamin D supplementation can be recommended especially for women who have PCOS, insulin resistance, or low anti-Mullerian hormone levels. Supplementation, however, should take into account possible toxic effects of high-dose vitamin D. To be able to recommend measuring vitamin D as a routine screening test and to better understand the effects of vitamin D and its supplementation on female reproductive functions, larger randomized controlled prospective studies are needed.
近年来，维生素 D 被定义为钙磷稳态和骨骼健康的主要调节剂，其非经典靶器官包括生殖器官。本综合研究侧重于维生素 D 对女性生殖功能的潜在影响。代谢维生素 D 的维生素 D 受体酶在中枢和外周生殖器官中均有表达。大多数研究表明，维生素 D 可能与性腺功能直接或间接相关。维生素 D 对生殖功能的影响可能与多囊卵巢综合征 (PCOS)、子宫肌瘤和子宫内膜异位症等疾病间接相关。在不孕治疗期间出现维生素 D 缺乏的情况下，可建议补充维生素 D，尤其是患有 PCOS、胰岛素抵抗或低抗苗勒管激素水平的女性。然而，补充剂应考虑高剂量维生素 D 的潜在毒性作用。为了能够推荐将维生素 D 测量作为常规筛查试验，并更好地了解维生素 D 及其补充剂对女性生殖功能的影响，需要进行更大规模的随机对照前瞻性研究。
