Carbohydrate Mouth Rinse Fails to Improve Four-Kilometer Cycling Time Trial Performance.

We investigated if a carbohydrate (CHO) mouth rinse may attenuate global fatigue and improve 4-km cycling time trial (TT) performance. After a preliminary session, cyclists ( = 9) performed a TT after a CHO or placebo (PLA) mouth rinse. Mean power output, time, and ratings of perceived exertion (RPE) were recorded throughout the TT. Twitch interpolation responses (%VA; voluntary activation and ∆Tw; delta peak twitch torque) were compared pre and post TT with traditional statistics and effect size (ES) analysis. Time-to-complete the 4 km and mean power output were comparable between CHO (386.4 ± 28.0 s) and PLA (385.4 ± 22.4 s). A lower central ( 0.054) and peripheral ( 0.02) fatigue in CHO than in PLA were suggested by an extremely-large ES in %VA (manipulation main effect: = 0.052, 1.18; manipulation-by-time interaction effect: = 0.08, 1.00) and an extremely, very-large ES in ∆Tw (manipulation main effect: = 0.07, 0.97; time-by-manipulation interaction effect: = 0.09, 0.89). The RPE increased slower in CHO than in PLA ( = 0.051; 0.7). The apparent reduction in global fatigue (central and peripheral) and RPE with only one CHO mouth rinse were not translated into improved TT performance. Further tests may be required to verify if these likely differences in global fatigue might represent an edge in the short-lasting cycling time trial performance.