Rises in Gastric Cancer and Exerts a Tumor-Promoting Function via / Axis.

PURPOSE

The aim of this paper was to investigate expression in gastric cancer (GC) and its effects on the biological behavior of gastric cancer cells (GCCs), and at exploring its potential mechanism.

METHODS

expression in the patients' tissues and serum was detected, and the correlation of the expression with the patients' pathological data and survival rate was analyzed. Overexpression or inhibitory vectors of , () and were constructed and transfected into GCCs to observe their effects on the cells' proliferation, invasion and apoptosis.

RESULTS

rose in GC and was higher in GC patients with a tumor size ≥5 cm, high stages (III+IV) and lymph node metastasis. High H19 expression was associated with the poorer survival rate of the patients, so serum had a certain diagnostic value for GC. knockdown could inhibit GCCs to proliferate and invade and induce their apoptosis. can be used as the target gene of , and can be negatively regulated by this miR, so knockdown or upregulation can weaken GCCs' biological behavior changes that were caused by H19 knockdown.

CONCLUSION

can be used as a biological indicator for diagnosing GC and predicting patients' poor prognosis. Additionally, it promotes GCCs to proliferate and invade through / axis.