Xu Yan, Selerio-Poely Tshepiso, Ye Xingru
Department of Periodontology, Stomatologic Hospital and College, Anhui Medical University, Hefei, China.
Key Laboratory of Oral Diseases Research of Anhui Province, Hefei, China.
J Periodontal Implant Sci. 2018 Feb 27;48(1):47-59. doi: 10.5051/jpis.2018.48.1.47. eCollection 2018 Feb.
To evaluate the clinical and microbiological effects of the local use of egg yolk immunoglobulin against (anti- IgY) as an adjunct to scaling and root planing (SRP) in the treatment of moderate to severe chronic periodontitis.
This was a randomized, placebo-controlled, double-blind trial involving 60 systematically healthy patients with moderate to severe chronic periodontitis. Subjects (n=20/group) were randomly assigned to receive SRP combined with subgingival irrigation of anti- IgY and anti- IgY mouthwash, subgingival irrigation of 0.2% chlorhexidine and 0.2% chlorhexidine mouthwash, or subgingival irrigation of placebo and placebo mouthwash for 4 weeks. Probing pocket depth, clinical attachment level, bleeding on probing, and the plaque index were evaluated at baseline and at 4 weeks. Subgingival plaque, gingival crevicular fluid, and saliva were simultaneously collected for microbiological analysis.
Our results showed that anti- IgY mouthwash was as effective as chlorhexidine at improving clinical parameters over a 4-week period. All the groups showed a significant reduction in levels of at 4 weeks. No significant difference was observed in the test group when compared to placebo regarding the reduction in the levels of Anti- IgY significantly suppressed the numbers of red complex bacteria (RCB) in subgingival plaque and saliva in comparison with placebo. No adverse effects were reported in any of the subjects.
Within the limitations of the study, the present investigation showed that passive immunization with anti IgY may prove to be effective in the treatment of chronic periodontitis due to its ability to improve clinical parameters and to reduce RCB. No significant differences were found between the anti- IgY and placebo groups in the reduction of
评估局部使用抗牙龈卟啉单胞菌蛋黄免疫球蛋白（抗IgY）作为中度至重度慢性牙周炎龈上洁治和根面平整（SRP）辅助治疗的临床和微生物学效果。
这是一项随机、安慰剂对照、双盲试验，纳入60例全身健康的中度至重度慢性牙周炎患者。受试者（每组n = 20）被随机分配接受SRP联合抗IgY龈下冲洗和抗IgY漱口水、0.2%氯己定龈下冲洗和0.2%氯己定漱口水，或安慰剂龈下冲洗和安慰剂漱口水，为期4周。在基线和4周时评估探诊深度、临床附着水平、探诊出血和菌斑指数。同时收集龈下菌斑、龈沟液和唾液进行微生物学分析。
我们的结果表明，在4周内，抗IgY漱口水在改善临床参数方面与氯己定一样有效。所有组在4周时均显示[具体细菌名称]水平显著降低。与安慰剂相比，试验组在[具体细菌名称]水平降低方面未观察到显著差异。与安慰剂相比，抗IgY显著抑制了龈下菌斑和唾液中红色复合体细菌（RCB）的数量。所有受试者均未报告不良反应。
在本研究的局限性范围内，目前的调查表明，抗IgY被动免疫可能因其改善临床参数和减少RCB的能力而被证明对慢性牙周炎有效。抗IgY组和安慰剂组在[具体细菌名称]减少方面未发现显著差异。
