Sundaram Gopalakrishnan, Theagarajan Ramakrishnan, Murthy Gomathi Dhakshina, Kanimozhi Gopalakrishnan
Department of Periodontics, Thai Moogambigai Dental College and Hospital Chennai, Tamil Nadu, India.
Department of Periodontics, Adhiparasakthi Dental College and Hospital, Melmaruvathur, Tamil Nadu, India.
J Indian Soc Periodontol. 2021 Sep-Oct;25(5):418-421. doi: 10.4103/jisp.jisp_509_20. Epub 2021 Aug 30.
Dental biofilm plays a crucial role in periodontal disease development. Mouth rinse is used to enhance oral hygiene after scaling and root planning (SRP). The aim of the study was to evaluate the clinical and microbiological effectiveness of a piper extract mouthwash against Chlorhexidine (CHX) in periodontitis patients.
Sixty patients with Stage II periodontitis participated in this study and were randomly divided into two groups (Group I - Stage II Grade A periodontitis patients were provided with prepared piper extract mouthwash and Group II - Stage II Grade A periodontitis patients were provided with 0.2% CHX). Plaque index, gingival index, sulcus bleeding index, probing pocket depth, and clinical attachment level were recorded at baseline and 30 days after SRP. Subgingival plaque samples were taken for microbial examination (colony-forming unit), quantification of using the real-time polymerase chain reaction at baseline, and 30 days after SRP.
Intragroup comparison for the clinical parameters showed statistically significant reduction in both the groups ( < 0.0001). Intergroup comparison for clinical parameters, there was no statistical significance seen after 30 days. Intragroup comparison for microbial analysis showed significant reduction in both the groups after 30 days ( < 0.0001). On intergroup comparison for microbial analysis, both the groups showed reduction after 30 days without significance.
Piper extract mouthwash (Group I) showed similar antimicrobial activity against when compared to 0.2% CHX mouthwash (Group II) that could be used as a substitute to CHX.
牙菌斑在牙周疾病发展中起关键作用。漱口水用于在龈下刮治和根面平整(SRP)后增强口腔卫生。本研究的目的是评估胡椒提取物漱口水对牙周炎患者中氯己定(CHX)的临床和微生物学有效性。
60例II期牙周炎患者参与本研究,并随机分为两组(I组 - II期A级牙周炎患者使用制备好的胡椒提取物漱口水,II组 - II期A级牙周炎患者使用0.2% CHX)。在基线和SRP后30天记录菌斑指数、牙龈指数、龈沟出血指数、探诊袋深度和临床附着水平。采集龈下菌斑样本进行微生物检查(菌落形成单位),在基线和SRP后30天使用实时聚合酶链反应进行定量。
两组临床参数的组内比较均显示有统计学意义的降低(<0.0001)。临床参数的组间比较在30天后未见统计学意义。微生物分析的组内比较显示两组在30天后均有显著降低(<0.0001)。微生物分析的组间比较显示两组在30天后均有降低但无显著性。
与0.2% CHX漱口水(II组)相比,胡椒提取物漱口水(I组)对[具体微生物]显示出相似的抗菌活性,可作为CHX的替代品。