Clin Nucl Med. 2018 Jun;43(6):458-459. doi: 10.1097/RLU.0000000000002059.
A 75-year-old woman with a history of sarcoidosis presenting with low cardiac output and complete right bundle-branch block underwent 4'-[methyl-C]-thiothymidine (4DST) PET/CT after cardiac MRI and FDG PET/CT for the evaluation of suspected cardiac sarcoidosis (CS) before treatment. Cardiac MRI revealed late gadolinium enhancement on the anterior-to-lateral and posterior wall, indicating CS. FDG uptake was shown on the anterior-to-lateral wall, but not on the posterior wall. In contrast, 4DST uptake was demonstrated on both anterior-to-lateral and posterior walls. Use of 4DST appears promising for detecting CS without dietary restriction, due to the lack of physiological uptake in myocardium.
一位 75 岁女性，有结节病病史，表现为心输出量低和完全性右束支传导阻滞，在接受心脏 MRI 和 FDG PET/CT 检查后，为了在治疗前评估疑似心脏结节病（CS），进行了 4'-[甲基-C]-硫代胸苷（4DST）PET/CT。心脏 MRI 显示前壁至侧壁和后壁的晚期钆增强，提示 CS。FDG 摄取显示在前壁至侧壁，但不在后壁。相比之下，4DST 摄取在前壁至侧壁和后壁均有显示。由于心肌中没有生理性摄取，因此使用 4DST 似乎有望在不限制饮食的情况下检测 CS。
