Negoro N, Kanayama Y, Takeda T, Amatsu K, Koda S, Inoue Y, Kim T, Okamura M, Inoue T
Rheumatol Int. 1987;7(1):7-11. doi: 10.1007/BF00267336.
We measured U1-RNP: anti-U1-RNP immune complexes (U1-RNP ICs) in patients with mixed connective tissue disease (MCTD) and systemic lupus erythematosus (SLE) to examine the clinical significance of circulating U1-RNP ICs. The level of U1-RNP ICs in 11 patients with MCTD was significantly higher than that in 22 normal subjects and there was a close correlation between the level of U1-RNP ICs and the clinical disease activity index of MCTD. In contrast, the level of U1-RNP ICs in 31 patients with SLE was not significantly higher than that in normal subjects and that was not correlated with the clinical disease activity index of SLE or the renal histologic activity index of lupus nephritis. We conclude that U1-RNP ICs are present in sera of patients with MCTD and SLE, and that the level of U1-RNP ICs may be closely associated with clinical disease activity in patients with MCTD.
我们检测了混合性结缔组织病（MCTD）和系统性红斑狼疮（SLE）患者的U1 - RNP：抗U1 - RNP免疫复合物（U1 - RNP ICs），以研究循环U1 - RNP ICs的临床意义。11例MCTD患者的U1 - RNP ICs水平显著高于22例正常受试者，且U1 - RNP ICs水平与MCTD的临床疾病活动指数密切相关。相比之下，31例SLE患者的U1 - RNP ICs水平并不显著高于正常受试者，且与SLE的临床疾病活动指数或狼疮性肾炎的肾脏组织学活动指数均无相关性。我们得出结论，U1 - RNP ICs存在于MCTD和SLE患者的血清中，且U1 - RNP ICs水平可能与MCTD患者的临床疾病活动密切相关。
