Davies G, Hess D, Jebson P
Anesthesiology. 1987 Jun;66(6):805-9. doi: 10.1097/00000542-198706000-00015.
A system for continuous Fick cardiac output measurement (CFCO) is described and compared to continuous electromagnetic pulmonary artery flow (EMCO) and intermittent thermodilution (TDCO) measurements. Oxygen consumption was determined from continuous respiratory gas exchange analysis and arterio-venous oxygen difference from fiberoptic oximetry. A computer calculated cardiac output and other variables every 20 s. Seven pigs were monitored for a total of 10 h, during which cardiac output was manipulated by obstructing venous return or infusing epinephrine. 1748 pairs of EMCO and CFCO values were compared. The best correlation was obtained when CFCO was advanced 20 s with respect to EMCO (R = .89, CFCO = .99 EMCO + .16). TDCO was compared to EMCO during periods of steady state (R = .85, TDCO = .89 EMCO + 1.25, N = 139). TDCO was also compared with simultaneous CFCO (R = .87, TDCO = .89 CFCO + 1.01, N = 251). CFCO is recommended as a reliable standard of continuous cardiac output measurement. It is not a real time measurement; the technique has a time lag of approximately 20 s which is the result of the time constant of the VO2 measurement. Sources for error are discussed with suggestions for improving quality control.
本文描述了一种用于连续测量菲克心输出量（CFCO）的系统，并将其与连续电磁肺动脉血流测量（EMCO）和间歇性热稀释法（TDCO）测量进行了比较。通过连续呼吸气体交换分析测定耗氧量，通过光纤血氧测定法测定动静脉血氧差。计算机每20秒计算一次心输出量和其他变量。对7头猪进行了总共10小时的监测，在此期间，通过阻塞静脉回流或输注肾上腺素来控制心输出量。比较了1748对EMCO和CFCO值。当CFCO相对于EMCO提前20秒时，相关性最佳（R = 0.89，CFCO = 0.99EMCO + 0.16）。在稳态期间将TDCO与EMCO进行比较（R = 0.85，TDCO = 0.89EMCO + 1.25，N = 139）。还将TDCO与同步CFCO进行比较（R = 0.87，TDCO = 0.89CFCO + 1.01，N = 251）。推荐CFCO作为连续心输出量测量的可靠标准。它不是实时测量；该技术存在约20秒的时间延迟，这是VO2测量时间常数的结果。讨论了误差来源并提出了改进质量控制的建议。
