Lockhart Shawn R, Berkow Elizabeth L
Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, GA.
Clin Microbiol Newsl. 2016 Jul;38(13):103-108. doi: 10.1016/j.clinmicnews.2016.06.001.
There are several new hot topics in antifungals and antifungal susceptibility testing. In this review, four topics of general interest to the clinical microbiology community are discussed. The first topic is the introduction of isavuconazole, a new triazole approved for clinical use in the US. The second is triazole resistance in isolates. A specific set of mutations are being found with greater frequency in isolates globally, including the US. The third topic of interest is a word of caution about antifungal susceptibility testing for caspofungin in isolates; some laboratories have reported susceptible isolates with high MIC values that would be interpreted as resistant. The final topic is an introduction to epidemiological cutoff values and their use in the clinical mycology laboratory.
抗真菌药物及抗真菌药敏试验有几个新的热门话题。在本综述中，讨论了临床微生物学界普遍感兴趣的四个话题。第一个话题是艾沙康唑的引入，这是一种在美国已获批用于临床的新型三唑类药物。第二个话题是分离株中的三唑类耐药性。在包括美国在内的全球分离株中，正在更频繁地发现一组特定的突变。第三个感兴趣的话题是关于曲霉菌分离株中卡泊芬净抗真菌药敏试验的一则警示；一些实验室报告了最低抑菌浓度（MIC）值较高的敏感分离株，而这些值会被判定为耐药。最后一个话题是流行病学截断值的介绍及其在临床真菌学实验室中的应用。
