抗真菌药敏试验的热点话题：一种新药、一种难缠的病菌、将卡泊芬净检测掩盖起来，以及解决等效曲线下倾问题
Hot topics in antifungal susceptibility testing: A new drug, a bad bug, sweeping caspofungin testing under the rug, and solving the ECV shrug.
作者信息
Lockhart Shawn R, Berkow Elizabeth L
机构信息
Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, GA.
出版信息
Clin Microbiol Newsl. 2016 Jul;38(13):103-108. doi: 10.1016/j.clinmicnews.2016.06.001.
Abstract
There are several new hot topics in antifungals and antifungal susceptibility testing. In this review, four topics of general interest to the clinical microbiology community are discussed. The first topic is the introduction of isavuconazole, a new triazole approved for clinical use in the US. The second is triazole resistance in isolates. A specific set of mutations are being found with greater frequency in isolates globally, including the US. The third topic of interest is a word of caution about antifungal susceptibility testing for caspofungin in isolates; some laboratories have reported susceptible isolates with high MIC values that would be interpreted as resistant. The final topic is an introduction to epidemiological cutoff values and their use in the clinical mycology laboratory.
摘要
抗真菌药物及抗真菌药敏试验有几个新的热门话题。在本综述中，讨论了临床微生物学界普遍感兴趣的四个话题。第一个话题是艾沙康唑的引入，这是一种在美国已获批用于临床的新型三唑类药物。第二个话题是分离株中的三唑类耐药性。在包括美国在内的全球分离株中，正在更频繁地发现一组特定的突变。第三个感兴趣的话题是关于曲霉菌分离株中卡泊芬净抗真菌药敏试验的一则警示；一些实验室报告了最低抑菌浓度（MIC）值较高的敏感分离株，而这些值会被判定为耐药。最后一个话题是流行病学截断值的介绍及其在临床真菌学实验室中的应用。
相似文献
1
Hot topics in antifungal susceptibility testing: A new drug, a bad bug, sweeping caspofungin testing under the rug, and solving the ECV shrug.
Clin Microbiol Newsl. 2016 Jul;38(13):103-108. doi: 10.1016/j.clinmicnews.2016.06.001.
2
Determination of isavuconazole susceptibility of Aspergillus and Candida species by the EUCAST method.
Antimicrob Agents Chemother. 2013 Nov;57(11):5426-31. doi: 10.1128/AAC.01111-13. Epub 2013 Aug 19.
3
Candida and candidaemia. Susceptibility and epidemiology.
Dan Med J. 2013 Nov;60(11):B4698.
4
Echinocandin and triazole antifungal susceptibility profiles for clinical opportunistic yeast and mold isolates collected from 2010 to 2011: application of new CLSI clinical breakpoints and epidemiological cutoff values for characterization of geographic and temporal trends of antifungal resistance.
J Clin Microbiol. 2013 Aug;51(8):2571-81. doi: 10.1128/JCM.00308-13. Epub 2013 May 29.
5
Etest ECVs/ECOFFs for Detection of Resistance in Prevalent and Three Nonprevalent spp. to Triazoles and Amphotericin B and Aspergillus spp. to Caspofungin: Further Assessment of Modal Variability.
Antimicrob Agents Chemother. 2021 Oct 18;65(11):e0109321. doi: 10.1128/AAC.01093-21. Epub 2021 Aug 9.
6
Comparative Evaluation of Disc Diffusion and E-test with Broth Micro-dilution in Susceptibility testing of Amphotericin B, Voriconazole and Caspofungin against Clinical Aspergillus isolates.
J Clin Diagn Res. 2015 Jan;9(1):DC04-7. doi: 10.7860/JCDR/2015/10467.5395. Epub 2015 Jan 1.
7
Monitoring Antifungal Resistance in a Global Collection of Invasive Yeasts and Molds: Application of CLSI Epidemiological Cutoff Values and Whole-Genome Sequencing Analysis for Detection of Azole Resistance in Candida albicans.
Antimicrob Agents Chemother. 2017 Sep 22;61(10). doi: 10.1128/AAC.00906-17. Print 2017 Oct.
8
Multicenter Study of Susceptibility of Aspergillus Species Isolated from Iranian University Hospitals to Seven Antifungal Agents.
Microbiol Spectr. 2022 Jun 29;10(3):e0253921. doi: 10.1128/spectrum.02539-21. Epub 2022 May 17.
9
In vitro susceptibility of 188 clinical and environmental isolates of Aspergillus flavus for the new triazole isavuconazole and seven other antifungal drugs.
Mycoses. 2011 Sep;54(5):e583-9. doi: 10.1111/j.1439-0507.2010.01996.x. Epub 2011 Apr 25.
10
Trends in the activity of mold-active azole agents against clinical isolates with and without alterations from Europe and North America (2017-2021).
J Clin Microbiol. 2024 Feb 14;62(2):e0114123. doi: 10.1128/jcm.01141-23. Epub 2024 Jan 9.
引用本文的文献
1
Antifungal Susceptibility Testing - The Times They Are a Changin'.
Clin Microbiol Newsl. 2019 May 15;41(10):85-90. doi: 10.1016/j.clinmicnews.2019.04.006.
本文引用的文献
1
Effects of Treated versus Untreated Polystyrene on Caspofungin In Vitro Activity against Candida Species.
J Clin Microbiol. 2016 Mar;54(3):734-8. doi: 10.1128/JCM.02659-15. Epub 2016 Jan 13.
2
Multiple Fungicide-Driven Alterations in Azole-Resistant Aspergillus fumigatus, Colombia, 2015.
Emerg Infect Dis. 2016 Jan;22(1):156-7. doi: 10.3201/eid2201.150978.
3
Isavuconazole versus voriconazole for primary treatment of invasive mould disease caused by Aspergillus and other filamentous fungi (SECURE): a phase 3, randomised-controlled, non-inferiority trial.
Lancet. 2016 Feb 20;387(10020):760-9. doi: 10.1016/S0140-6736(15)01159-9. Epub 2015 Dec 10.
4
Clinical Practice Guideline for the Management of Candidiasis: 2016 Update by the Infectious Diseases Society of America.
Clin Infect Dis. 2016 Feb 15;62(4):e1-50. doi: 10.1093/cid/civ933. Epub 2015 Dec 16.
5
Molecular Characterization of a Voriconazole-Resistant, Posaconazole-Susceptible Aspergillus fumigatus Isolate in a Lung Transplant Recipient in the United States.
Antimicrob Agents Chemother. 2015 Nov 16;60(2):1129-33. doi: 10.1128/AAC.01130-15. Print 2016 Feb.
6
First Detection of TR34 L98H and TR46 Y121F T289A Cyp51 Mutations in Aspergillus fumigatus Isolates in the United States.
J Clin Microbiol. 2016 Jan;54(1):168-71. doi: 10.1128/JCM.02478-15. Epub 2015 Oct 21.
7
Azole Resistance in Aspergillus fumigatus: Can We Retain the Clinical Use of Mold-Active Antifungal Azoles?
Clin Infect Dis. 2016 Feb 1;62(3):362-8. doi: 10.1093/cid/civ885. Epub 2015 Oct 20.
8
In Vitro Activity of Isavuconazole and Comparators against Clinical Isolates of the Mucorales Order.
Antimicrob Agents Chemother. 2015 Dec;59(12):7735-42. doi: 10.1128/AAC.01919-15. Epub 2015 Oct 5.
9
Multicenter study of epidemiological cutoff values and detection of resistance in Candida spp. to anidulafungin, caspofungin, and micafungin using the Sensititre YeastOne colorimetric method.
Antimicrob Agents Chemother. 2015 Nov;59(11):6725-32. doi: 10.1128/AAC.01250-15. Epub 2015 Aug 17.
10
Multi-triazole-resistant Aspergillus fumigatus infections in Australia.
Mycoses. 2015 Jun;58(6):350-5. doi: 10.1111/myc.12324. Epub 2015 Apr 17.
Zotero 插件