Wang Di, Li Qian, Qu Yidi, Wang Mengya, Li Lanzhou, Liu Yang, Li Yu
Engineering Research Center of Chinese Ministry of Education for Edible and Medicinal Fungi, Jilin Agricultural University, Changchun, Jilin 130118, P.R. China.
School of Life Sciences, Jilin University, Changchun, Jilin 130012, P.R. China.
Exp Ther Med. 2018 Apr;15(4):3633-3638. doi: 10.3892/etm.2018.5810. Epub 2018 Jan 30.
, a precious edible mushroom, displays anti-bacterial and anti-inflammatory activities; however, its immunomodulatory effect has not been studied yet. The present study aimed to investigate whether polysaccharide compositions of polysaccharides (GIPS) possess immunomodulatory and immuno-enhancing effects in a Cyclophosphamide monohydrate (CTX)-induced BALB/c mice model. The 28-day GIPS administration at doses of 0.1, 0.3 and 0.9 g/kg remarkably reversed the bodyweight loss, increased the thymic index and promoted T lymphocyte proliferation in CTX-induced immunosuppressed mice. GIPS significantly raised the serum levels of immunoglobulin (Ig)A and IgG, promoted the production of interleukins (ILs), including IL-2, IL-3 and IL-6, interferons, including interferon (IFN)-α and IFN-γ, and monocyte chemotactic protein 1 in the spleen, which resulted in accelerating recovery of immunosuppression. Finally, GIPS showed anti-oxidative effects indicated by the increased superoxide dismutase levels in the serum and spleen, and the reduced level of reactive oxygen species in the spleen. The results of the current study demonstrated that GIPS positively adjusts the immune system, which may serve as a potential immunostimulatory agent.
[某种珍贵的食用菌]具有抗菌和抗炎活性；然而，其免疫调节作用尚未得到研究。本研究旨在探讨[某种多糖（GIPS）]的多糖成分在环磷酰胺一水合物（CTX）诱导的BALB/c小鼠模型中是否具有免疫调节和免疫增强作用。以0.1、0.3和0.9 g/kg的剂量连续28天给予GIPS，可显著逆转CTX诱导的免疫抑制小鼠的体重减轻，增加胸腺指数并促进T淋巴细胞增殖。GIPS显著提高血清免疫球蛋白（Ig）A和IgG水平，促进包括白细胞介素（ILs）-2、IL-3和IL-6、干扰素（IFNs）-α和IFN-γ以及脾脏中单核细胞趋化蛋白1的产生，从而加速免疫抑制的恢复。最后，GIPS表现出抗氧化作用，血清和脾脏中超氧化物歧化酶水平升高，脾脏中活性氧水平降低表明了这一点。本研究结果表明，GIPS可正向调节免疫系统，可能作为一种潜在的免疫刺激剂。
