Lee Dae-Young, Park Chan Woong, Lee Sue Jung, Park Hye-Ryung, Kim Su Hwan, Son Seung-U, Park Jiyong, Shin Kwang-Soon
Department of Food Science and Biotechnology, Kyonggi University, Suwon, South Korea.
R&D Center, Vital Beautie Research Institute, AmorePacific Corporation, Yongin, South Korea.
Front Pharmacol. 2019 Nov 26;10:1411. doi: 10.3389/fphar.2019.01411. eCollection 2019.
has long been used as natural medicine and health food all over the world. Cancer is a major cause of death worldwide and its prognosis likely depends on the immune system during tumor treatment. In this study, ginseng berry polysaccharides were evaluated for their immunostimulant and anti-cancer effects. Ginseng berry polysaccharide portion (GBPP) was used to investigate its effects on anti-complementary activity, peritoneal macrophage activation, and natural killer (NK) cell cytotoxicity. Moreover, both intravenous () and oral administration of GBPP prior to B16-BL6 melanoma implantation in mice was evaluated. GBPP significantly increased the anti-complementary activity and cytokine production including interleukin (IL)-6, IL-12, and tumor necrosis factor (TNF)-α, dose-dependently. Splenocytes obtained after administration of GBPP showed cytolytic activity in Yac-1 cells in proportion to the E/T ratio. In addition, GBPP enhanced the production of interferon (IFN)-γ and granzyme B of NK cells. For the experimental lung cancer, compared with control mice, GBPP delivered by suppressed cancer by 48% at 100 μg/mouse, while a 37% reduction was achieved by oral administration. Deficient of NK cells in animal model demonstrated that the anti-cancer effect of GBPP was through NK cell activation. Results of this study suggest that ginseng berry polysaccharides, owing to their modulation of the immune response, can be a potential curative applicant for the prevention and treatment of tumors.
长期以来，它在世界各地一直被用作天然药物和保健食品。癌症是全球主要的死亡原因，其预后可能取决于肿瘤治疗期间的免疫系统。在本研究中，对人参果多糖的免疫刺激和抗癌作用进行了评估。用人参果多糖部分（GBPP）研究其对抗补体活性、腹腔巨噬细胞活化和自然杀伤（NK）细胞细胞毒性的影响。此外，还评估了在小鼠植入B16-BL6黑色素瘤之前静脉注射（）和口服GBPP的效果。GBPP显著增加抗补体活性和细胞因子产生，包括白细胞介素（IL）-6、IL-12和肿瘤坏死因子（TNF）-α，呈剂量依赖性。给予GBPP后获得的脾细胞在Yac-1细胞中显示出与E/T比率成比例的细胞溶解活性。此外，GBPP增强了NK细胞干扰素（IFN）-γ和颗粒酶B的产生。对于实验性肺癌，与对照小鼠相比，静脉注射GBPP以100μg/小鼠给药时可抑制癌症48%，而口服给药可使癌症减少37%。动物模型中NK细胞缺陷表明GBPP的抗癌作用是通过NK细胞活化实现的。本研究结果表明，人参果多糖由于其对免疫反应的调节作用，可能是预防和治疗肿瘤的潜在治疗药物。
