Maya-Manzano José María, Pusch Gudrun, Ebner von Eschenbach Cordula, Bartusel Elke, Belzner Thomas, Karg Erwin, Bardolatzy Ulrich, Scheja Michael, Schmidt-Weber Carsten, Buters Jeroen
Center of Allergy & Environment (ZAUM), Member of the German Center for Lung Research (DZL), Technical University and Helmholtz Center, Munich, Germany.
Philips Research China, Shanghai, China.
Clin Transl Allergy. 2022 Apr 21;12(4):e12137. doi: 10.1002/clt2.12137. eCollection 2022 Apr.
Indoor allergens (i.e. from mite, cat and dog) are carried by airborne particulate matter. Thus, removal of particles would reduce allergen exposure. This work aims to assess the performance of air filtration on particulate matter and thus allergen removal in 22 bedrooms.
Indoor air was sampled (with and without air filtration) with a cascade impactor and allergens were measured using enzyme-linked immunosorbent assay (ELISA). Particulate matter (including ultrafine particles) was also monitored.
The median of allergen reduction was 75.2% for Der f 1 ( < 0.001, = 20), 65.5% for Der p 1 ( = 0.066, = 4), 76.6% for Fel d 1 ( < 0.01, = 21) and 89.3% for Can f 1 ( < 0.01, = 10). For size fractions, reductions were statistically significant for Der f 1 (all < 0.001), Can f 1 (PM and PM, < 0.01) and Fel d 1 (PM, < 0.01), but not for Der p 1 (all > 0.05). PM was reduced in all fractions ( < 0.001). The allergens were found in all particle size fractions, higher mite allergens in the PM and for pet allergens in the PM.
Air filtration was effective in removing mites, cat and dog allergens and also particulate matter from ambient indoor air, offering a fast and simple solution to mitigate allergen exposome.
室内过敏原（即来自螨虫、猫和狗的过敏原）由空气颗粒物携带。因此，去除颗粒物将减少过敏原暴露。本研究旨在评估空气过滤对颗粒物的去除性能，进而评估其对22间卧室中过敏原的去除效果。
使用多级冲击采样器对室内空气进行采样（有空气过滤和无空气过滤两种情况），并采用酶联免疫吸附测定法（ELISA）测量过敏原。同时还对颗粒物（包括超细颗粒物）进行监测。
粉尘螨变应原Der f 1的过敏原减少中位数为75.2%（P<0.001，n = 20），屋尘螨变应原Der p 1为65.5%（P = 0.066，n = 4），猫过敏原Fel d 1为76.6%（P<0.01，n = 21），狗过敏原Can f 1为89.3%（P<0.01，n = 10）。对于不同粒径范围的颗粒物，Der f 1（所有P<0.001）、Can f 1（PM和PM，P<0.01）和Fel d 1（PM，P<0.01）的减少具有统计学意义，但Der p 1没有（所有P>0.05）。所有粒径范围的PM均有所减少（P<0.001）。在所有粒径范围内均发现了过敏原，PM中螨虫过敏原含量较高，PM中宠物过敏原含量较高。
空气过滤可有效去除室内环境空气中的螨虫、猫和狗过敏原以及颗粒物，为减轻过敏原暴露提供了一种快速简便的解决方案。
