Kostakis Ioannis D, Agrogiannis George, Vaiopoulos Aristeidis G, Mylona Eleni, Patsouris Efstratios, Kouraklis Gregory, Koutsilieris Michael
Second Department of Propedeutic Surgery, "Laiko" General Hospital, National and Kapodistrian University of Athens, Medical School, Athens, Greece.
Department of Experimental Physiology, National and Kapodistrian University of Athens, Medical School, Athens, Greece.
APMIS. 2015 Jul;123(7):629-37. doi: 10.1111/apm.12397. Epub 2015 May 22.
Kisspeptins, the products of the KISS1 gene have tumor suppressing and antimetastatic properties. We aimed to study KISS1 and KISS1R expression in colorectal cancer. We analyzed KISS1 and KISS1R expression using immunohistochemistry and image analysis in normal and malignant tissue samples from 111 patients with colorectal adenocarcinoma. KISS1 expression was much higher in the normal than in the malignant colonic mucosa. Regarding malignant tissues, KISS1 levels were higher in larger tumors, in stage III and IV cancers, in cancers with lymph node metastasis and in tumors located in the distal part of the large intestine. Patients with greater KISS1 levels had worse prognosis. No KISS1R expression was detected in normal or malignant tissues or in liver metastases. KISS1 expression is reduced during the malignant transformation of the colonic mucosa. However, larger and advanced colorectal cancers express more KISS1, without reaching the former normal levels, and increased KISS1 levels are associated with worse prognosis. Finally, neither the normal nor the malignant colonic epithelial cells produce KISS1R.
亲吻素是KISS1基因的产物，具有肿瘤抑制和抗转移特性。我们旨在研究KISS1和KISS1R在结直肠癌中的表达情况。我们采用免疫组织化学和图像分析方法，对111例结直肠腺癌患者的正常组织和恶性组织样本中的KISS1和KISS1R表达进行了分析。KISS1在正常结肠黏膜中的表达远高于恶性结肠黏膜。在恶性组织中，KISS1水平在较大肿瘤、III期和IV期癌症、有淋巴结转移的癌症以及位于大肠远端的肿瘤中更高。KISS1水平较高的患者预后较差。在正常组织、恶性组织或肝转移灶中均未检测到KISS1R表达。在结肠黏膜的恶性转化过程中，KISS1表达降低。然而，较大且进展期的结直肠癌表达更多的KISS1，但未达到先前的正常水平，且KISS1水平升高与较差的预后相关。最后，正常和恶性结肠上皮细胞均不产生KISS1R。
