INSERM, UMR_S 1138, Cordeliers Research Center, Team Cancer, Immune Control and Escape, F-75006 Paris, France; University Paris Descartes Paris 5, Sorbonne Paris Cite, UMR_S 1138, Centre de Recherche des Cordeliers, F-75006 Paris, France; University UPMC Paris 6, Sorbonne University, UMR_S1138-75006 Paris, France; Department of Medical Oncology, Georges Pompidou European Hospital, University Descartes Paris 5, Paris, France.
INSERM, UMR_S 1138, Cordeliers Research Center, Team Cancer, Immune Control and Escape, F-75006 Paris, France; University Paris Descartes Paris 5, Sorbonne Paris Cite, UMR_S 1138, Centre de Recherche des Cordeliers, F-75006 Paris, France; University UPMC Paris 6, Sorbonne University, UMR_S1138-75006 Paris, France; Programme Cartes d'Identité des Tumeurs, Ligue Nationale Contre le Cancer, Paris, France.
Curr Opin Immunol. 2018 Apr;51:97-102. doi: 10.1016/j.coi.2018.03.005. Epub 2018 Mar 16.
Tumors are highly heterogeneous structures where malignant cells interact with a large variety of cell populations, including a clinically-relevant immune component. We review and compare the most recent methods designed to analyze and quantify the composition of immune and stromal microenvironment of tumors and discuss their use in identification of patients for high risk of progression. If the impact of the various immune components on patient's relapse share common rules in most malignancies, clear cell renal cell tumors behave differently with regards to immunity. We focus on this specific pathology to show how the tumor interacts with the host's immune system and how this intricate relationship shapes the clinical outcome.
肿瘤是高度异质的结构，其中恶性细胞与多种细胞群体相互作用，包括临床上相关的免疫成分。我们回顾和比较了最近设计用于分析和量化肿瘤免疫和基质微环境组成的方法，并讨论了它们在识别高危进展患者中的应用。如果各种免疫成分对患者复发的影响在大多数恶性肿瘤中具有共同的规律，那么透明细胞肾细胞肿瘤在免疫方面的表现则不同。我们专注于这种特定的病理学，以展示肿瘤如何与宿主的免疫系统相互作用，以及这种复杂的关系如何塑造临床结果。
