Kadowaki M H, Levett J M, Manjoney D L, Wilson C A, Glagov S
Virchows Arch A Pathol Anat Histopathol. 1987;411(2):173-7. doi: 10.1007/BF00712741.
To assess the healing process of various intracardiac prosthetic graft materials, we inserted autologous left atrium (control), autologous pericardium (AP), bovine pericardium (BP), polytetrafluoroethylene (PTEE) and woven Dacron (WD) patches into excised defects in the left atrial wall of 15 dogs. Two patches were implanted into each heart utilizing six patches for each material. Three months after graft placement, histological examination revealed chronic inflammation and fibrosis for all materials. Dense connective tissue surrounded the grafts in which fibrosis was most prominent. Cartilage formation occurred in 11 grafts: 5 BP, 4 PTFE, 1 control and 1 AP site. This change was not evident with WD. The extent of cartilage formation was greatest in BP. Bone formation occurred in 3 BP sites. 2 PTFE and 1 control site. Quantitative calcium concentrations were similar for all of the grafts without bone formation. Calcium concentrations at sites with bone formation averaged 15.13 mg/g +/- 6.39 mg/g compared to 0.939 +/- 0.419 for sites without bone formation (p less than 0.0001). We conclude that while inflammation, fibrosis and connective tissue thickening occur with healing of all graft materials, cartilage and bone formation differ with respect to the material employed.
为评估各种心内人工移植材料的愈合过程，我们将自体左心房（对照）、自体心包（AP）、牛心包（BP）、聚四氟乙烯（PTEE）和编织涤纶（WD）补片植入15只犬左心房壁的切除缺损处。每颗心脏植入两片补片，每种材料使用六片补片。移植后三个月，组织学检查显示所有材料均有慢性炎症和纤维化。移植片周围有致密结缔组织，其中纤维化最为明显。11个移植片出现软骨形成：5个BP、4个PTFE、1个对照和1个AP部位。WD未出现这种变化。软骨形成程度在BP中最大。3个BP部位、2个PTFE和1个对照部位出现骨形成。所有无骨形成的移植片的钙定量浓度相似。有骨形成部位的钙浓度平均为15.13mg/g±6.39mg/g，而无骨形成部位为0.939±0.419（p＜0.0001）。我们得出结论，虽然所有移植材料愈合时都会出现炎症、纤维化和结缔组织增厚，但软骨和骨形成因所用材料而异。
