Xing Bing, Cao Ailin, Sun Wei, Hou Xiyan
Department of Cardiology, Jining No. 1 People's Hospital, Jining, Shandong 273200, P.R. China.
Department of Cardiology, Affiliated Hospital of Jining Medical University, Jining, Shandong 272029, P.R. China.
Exp Ther Med. 2018 Apr;15(4):3769-3774. doi: 10.3892/etm.2018.5872. Epub 2018 Feb 15.
The relationship between left ventricular diastolic and systolic dyssynchrony in hypertrophic cardiomyopathy (HCM) was investigated by single-cardiac real-time three-dimensional ultrasonography. A total of 52 patients with HCM were selected in Jining No. 1 People's Hospital from July 2016 to June 2017. Additionally, a total of 52 healthy people were selected to serve as the control group. All participants received real-time two- and three-dimensional ultrasonography to evaluate left ventricular morphology, function and systolic and diastolic function. The relevant parameters included left ventricular end-diastolic volume (LVEDV), left ventricular end-systolic volume (LVESV), left ventricular ejection fraction (LVEF), end-systolic/diastolic sphericity index (ESSI/EDSI), systolic dyssynchrony index (SDI), diastolic dyssynchrony index (DDI), dispersion end systole (DISPES), diastolic dyssynchrony index-late (DDI-late) and dispersion end diastole (DISPED-late). The LVEF of observation group was significantly lower than that of the control group, while LVEDV, LVESV, E/A and E/Ea were significantly higher than those in control group (P<0.05); EDSI, DDI-late and DISPED-late were significantly higher in observation than in control group (P<0.05); ESSI, SDI and DISPES in observation were significantly higher than those in control group (P<0.05); The 16-segment time-volume curve of observation group was disordered without synchronization, while the curve of control group was regular and smooth with synchronization; Pearson's correlation analysis showed that SDI and DDI were positively correlated (P<0.05). In conclusion, three-dimensional ultrasonography can be used to effectively evaluate left ventricular diastolic and systolic dyssynchrony in HCM. The severity of diastolic is positively correlated with systolic dyssynchrony.
采用单心脏实时三维超声心动图研究肥厚型心肌病（HCM）患者左心室舒张期与收缩期不同步之间的关系。2016年7月至2017年6月期间，济宁市第一人民医院共选取52例HCM患者。另外，选取52名健康人作为对照组。所有参与者均接受实时二维和三维超声心动图检查，以评估左心室形态、功能以及收缩和舒张功能。相关参数包括左心室舒张末期容积（LVEDV）、左心室收缩末期容积（LVESV）、左心室射血分数（LVEF）、收缩末期/舒张末期球形指数（ESSI/EDSI）、收缩不同步指数（SDI）、舒张不同步指数（DDI）、收缩末期离散度（DISPES）、舒张晚期不同步指数（DDI-late）和舒张末期离散度（DISPED-late）。观察组的LVEF显著低于对照组，而LVEDV、LVESV、E/A和E/Ea显著高于对照组（P<0.05）；观察组的EDSI、DDI-late和DISPED-late显著高于对照组（P<0.05）；观察组的ESSI、SDI和DISPES显著高于对照组（P<0.05）；观察组的16节段时间-容积曲线紊乱且不同步，而对照组曲线规则、平滑且同步；Pearson相关性分析显示SDI与DDI呈正相关（P<0.05）。总之，三维超声心动图可有效评估HCM患者左心室舒张期和收缩期不同步情况。舒张期严重程度与收缩期不同步呈正相关。
