Department of Oncology, CRUK-MRC Oxford Centre, Gray Laboratory, University of Oxford, Oxford, UK.
Faculty of Medicine, Imperial College, London, UK.
Br J Radiol. 2019 Jan;92(1093):20180097. doi: 10.1259/bjr.20180097. Epub 2018 Mar 20.
A summary of the key aspects of radiobiological modelling is provided, based on the theoretical and practical concepts of the linear quadratic model, which gradually replaced other numerical approaches. The closely related biological effective dose concept is useful in many clinical applications. Biological effective dose formulations in conventional photon-based radiotherapy continue to be developed, and can be extended to the now increasingly used proton and ion-beam therapy, to very low or high dose ranges, the dose rate effect, hypoxia and repopulation. Such established and new research developments will be of interest to clinicians, physicists and biologists to better understand the processes underlying radiotherapy and assist their collaborative efforts to make radiotherapy safer and more effective.
提供了放射生物学建模的关键方面的摘要,基于线性二次模型的理论和实践概念,该模型逐渐取代了其他数值方法。密切相关的生物有效剂量概念在许多临床应用中很有用。在传统的基于光子的放射治疗中,生物有效剂量公式不断得到发展,并可扩展到现在越来越多地使用的质子和离子束治疗,以及非常低或高剂量范围、剂量率效应、缺氧和再增殖。这些既定的和新的研究进展将引起临床医生、物理学家和生物学家的兴趣,以更好地了解放射治疗背后的过程,并协助他们进行合作,使放射治疗更安全、更有效。