Suppr超能文献

实用放射生物学建模的发展。

The evolution of practical radiobiological modelling.

机构信息

Department of Oncology, CRUK-MRC Oxford Centre, Gray Laboratory, University of Oxford, Oxford, UK.

Faculty of Medicine, Imperial College, London, UK.

出版信息

Br J Radiol. 2019 Jan;92(1093):20180097. doi: 10.1259/bjr.20180097. Epub 2018 Mar 20.

Abstract

A summary of the key aspects of radiobiological modelling is provided, based on the theoretical and practical concepts of the linear quadratic model, which gradually replaced other numerical approaches. The closely related biological effective dose concept is useful in many clinical applications. Biological effective dose formulations in conventional photon-based radiotherapy continue to be developed, and can be extended to the now increasingly used proton and ion-beam therapy, to very low or high dose ranges, the dose rate effect, hypoxia and repopulation. Such established and new research developments will be of interest to clinicians, physicists and biologists to better understand the processes underlying radiotherapy and assist their collaborative efforts to make radiotherapy safer and more effective.

摘要

提供了放射生物学建模的关键方面的摘要,基于线性二次模型的理论和实践概念,该模型逐渐取代了其他数值方法。密切相关的生物有效剂量概念在许多临床应用中很有用。在传统的基于光子的放射治疗中,生物有效剂量公式不断得到发展,并可扩展到现在越来越多地使用的质子和离子束治疗,以及非常低或高剂量范围、剂量率效应、缺氧和再增殖。这些既定的和新的研究进展将引起临床医生、物理学家和生物学家的兴趣,以更好地了解放射治疗背后的过程,并协助他们进行合作,使放射治疗更安全、更有效。

相似文献

1
The evolution of practical radiobiological modelling.
Br J Radiol. 2019 Jan;92(1093):20180097. doi: 10.1259/bjr.20180097. Epub 2018 Mar 20.
3
Radiobiological modelling of dose-gradient effects in low dose rate, high dose rate and pulsed brachytherapy.
Phys Med Biol. 2006 Sep 7;51(17):4399-411. doi: 10.1088/0031-9155/51/17/018. Epub 2006 Aug 15.
4
Radiation repair models for clinical application.
Br J Radiol. 2019 Jan;92(1093):20180070. doi: 10.1259/bjr.20180070. Epub 2018 Feb 28.
5
Optimization of radiobiological effects in intensity modulated proton therapy.
Med Phys. 2005 Feb;32(2):455-65. doi: 10.1118/1.1851925.
6
THE ROLE OF PARTICLE SPECTRA IN MODELING THE RELATIVE BIOLOGICAL EFFECTIVENESS OF PROTON RADIOTHERAPY BEAMS.
Radiat Prot Dosimetry. 2019 May 1;183(1-2):251-254. doi: 10.1093/rpd/ncy268.
7
9
A TCP-NTCP estimation module using DVHs and known radiobiological models and parameter sets.
J Appl Clin Med Phys. 2004 Winter;5(1):50-63. doi: 10.1120/jacmp.v5i1.1970. Epub 2004 Jan 1.
10
Clinical radiobiology of proton therapy: modeling of RBE.
Acta Oncol. 2017 Nov;56(11):1374-1378. doi: 10.1080/0284186X.2017.1343496. Epub 2017 Aug 18.

引用本文的文献

4
Radiotherapy treatment interruptions during the Covid-19 pandemic: The UK experience and implications for radiobiology training.
Radiat Phys Chem Oxf Engl 1993. 2022 Nov;200:110214. doi: 10.1016/j.radphyschem.2022.110214. Epub 2022 May 6.
6
A Multi-Compartment Model of Glioma Response to Fractionated Radiation Therapy Parameterized Time-Resolved Microscopy Data.
Front Oncol. 2022 Feb 4;12:811415. doi: 10.3389/fonc.2022.811415. eCollection 2022.
7
8
Clinical Radiobiology of Fast Neutron Therapy: What Was Learnt?
Front Oncol. 2020 Sep 15;10:1537. doi: 10.3389/fonc.2020.01537. eCollection 2020.
10
Use of radiobiology in medical jurisprudence, with particular reference to delays in diagnosis and therapeutic onset.
Br J Radiol. 2019 Dec;92(1104):20190672. doi: 10.1259/bjr.20190672. Epub 2019 Nov 7.

本文引用的文献

1
Hypofractionated high-energy proton-beam irradiation is an alternative treatment for WHO grade I meningiomas.
Acta Neurochir (Wien). 2017 Dec;159(12):2391-2400. doi: 10.1007/s00701-017-3352-4. Epub 2017 Oct 24.
2
Professor Jack Fowler and Sir Oliver Scott.
Br J Radiol. 2017 Jan;90(1069):20160904o. doi: 10.1259/bjr.20160904.o.
3
Adaptation of the microdosimetric kinetic model to hypoxia.
Phys Med Biol. 2016 Nov 7;61(21):7586-7599. doi: 10.1088/0031-9155/61/21/7586. Epub 2016 Oct 7.
5
Alternative models for estimating the radiotherapy retreatment dose for the spinal cord.
Int J Radiat Biol. 2014 Sep;90(9):731-41. doi: 10.3109/09553002.2014.925151. Epub 2014 Jul 7.
7
Estimation of a self-consistent set of radiobiological parameters from hypofractionated versus standard radiation therapy of prostate cancer.
Int J Radiat Oncol Biol Phys. 2013 Apr 1;85(5):e231-7. doi: 10.1016/j.ijrobp.2012.11.033. Epub 2013 Jan 17.
8
Modelling of the oxygen enhancement ratio for ion beam radiation therapy.
Phys Med Biol. 2011 Jun 7;56(11):3251-68. doi: 10.1088/0031-9155/56/11/006. Epub 2011 May 4.
10
21 years of biologically effective dose.
Br J Radiol. 2010 Jul;83(991):554-68. doi: 10.1259/bjr/31372149.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验