Department of Psychology, George Mason University, Fairfax, VA, USA.
Department of Psychology, George Mason University, Fairfax, VA, USA.
J Psychiatr Res. 2018 Jul;102:14-22. doi: 10.1016/j.jpsychires.2018.03.005. Epub 2018 Mar 14.
Stress and affect have been implicated in the maintenance of binge eating for women with symptoms of bulimia nervosa (BN). Neuroimaging and ecological momentary assessment (EMA) have separately examined how these variables may contribute to eating disorder behavior. Though both methodologies have their own strengths, it's unclear how either methodology might inform the other. This study examined the impact of individual differences in neural reactivity to food cues following acute stress on the trajectories of positive affect (PA) and negative affect (NA) surrounding binge eating. Women (n = 16) with BN symptoms viewed palatable food cues before and after a stress induction in the scanner. For two weeks, participants responded to prompts assessing affect and binge episodes several times a day. EMA data revealed NA increased and PA decreased before binge episodes in the natural environment. Additionally, NA decreased while PA increased following binge episodes. Changes in activation in the ACC, amygdala, and the vmPFC significantly moderated the relationship of affect to binge eating. However, lateral differences of each brain region uniquely moderator the trajectory of PA, NA, or both to binge eating. Specifically, those with less change in BOLD response reported significantly increasing NA and decreasing PA prior to binges, while women with greater decreases reported no change in affect. Following binge eating, individuals with decreased change in BOLD response reported decreasing NA and increasing PA. This may suggest individual differences in neural response to food cues under stress appear to underlie affect driven theory on the antecedents to binge eating.
压力和情绪在维持暴食症女性的暴食行为中起作用（BN）。神经影像学和生态瞬时评估（EMA）分别研究了这些变量如何导致饮食失调行为。虽然这两种方法都有其自身的优势，但不清楚这两种方法中的任何一种方法如何相互提供信息。本研究探讨了个体对急性应激后食物线索的神经反应差异对暴食相关正性情绪（PA）和负性情绪（NA）轨迹的影响。有 BN 症状的女性（n=16）在扫描仪中进行了应激诱导前后观看美味食物线索。两周内，参与者每天多次对评估情绪和暴食发作的提示做出回应。EMA 数据显示，在自然环境中，暴食发作前 NA 增加，PA 减少。此外，暴食发作后 NA 减少，PA 增加。ACC、杏仁核和 vmPFC 的激活变化显著调节了情绪与暴食的关系。然而，每个大脑区域的外侧差异独特地调节了 PA、NA 或两者与暴食的轨迹。具体来说，那些 BOLD 反应变化较小的人在暴食前报告说 NA 明显增加，PA 减少，而那些 BOLD 反应减少较大的人则没有情绪变化。暴食后，BOLD 反应变化减少的人报告说 NA 减少，PA 增加。这可能表明，应激下个体对食物线索的神经反应差异可能是暴食前影响理论的基础。
