Department of Psychology, George Mason University, Fairfax, VA, USA.
Department of Psychology, George Mason University, Fairfax, VA, USA.
J Psychiatr Res. 2017 Sep;92:15-23. doi: 10.1016/j.jpsychires.2017.03.017. Epub 2017 Mar 25.
Women with symptoms of bulimia nervosa (BN) exhibit decreased response to visual food cues in several limbic and frontal regions compared to controls. Stress causes decreased blood oxygenation level dependent (BOLD) response in these regions in non-clinical samples; there is a lack of data on this topic in BN. This study examined the impact of individual differences in neural reactivity to palatable food cues following acute stress on stress-binge trajectories in everyday life. 16 women with BN symptoms viewed palatable food cues prior to and immediately following an acute stress induction in the scanner. Participants then responded to a series of prompts assessing daily ratings of stress and binge episodes for a period of two weeks. Decreased BOLD signal was observed in response to food cues pre to post stress in the anterior cingulate cortex (ACC), amygdala, and ventromedial prefrontal cortex (vmPFC). Ecological momentary assessment data collection demonstrated that stress increased prior to binge episodes in the natural environment, and decreased following. Changes in activation in the ACC, precuneus, and dorsolateral prefrontal cortex (dlPFC) significantly moderated the relationship of stress to binge eating in daily life, such that women who exhibited decreased response reported significantly increasing stress prior to binges, while women who did not exhibit decreases reported no significant change in stress prior to binges. Individual differences in neural response to food cues under stress appear to underlie distinct antecedants to binge eating.
患有贪食症（BN）症状的女性与对照组相比，在几个边缘和额叶区域对视觉食物线索的反应减弱。在非临床样本中，应激会导致这些区域的血氧水平依赖（BOLD）反应减少；关于 BN 这一主题的数据缺乏。本研究考察了个体对急性应激后美味食物线索的神经反应差异对日常生活中应激暴食轨迹的影响。16 名有 BN 症状的女性在扫描仪中接受急性应激诱导之前和之后观看美味食物线索。然后，参与者在两周的时间内对一系列评估日常压力和暴食发作的提示做出回应。与应激前相比，腹侧前扣带回皮层（ACC）、杏仁核和腹内侧前额叶皮层（vmPFC）对食物线索的 BOLD 信号在应激后减少。生态瞬时评估数据采集表明，应激在自然环境中先于暴食发作增加，应激后减少。ACC、楔前叶和背外侧前额叶皮层（dlPFC）的激活变化显著调节了应激与日常生活中暴食的关系，使得反应减弱的女性报告说在暴食前压力显著增加，而没有表现出减少的女性报告说在暴食前压力没有显著变化。应激下对食物线索的神经反应的个体差异似乎是暴食发作的不同前兆的基础。
