Lu Jianyun, Wu Kathy, Zeng Qinghai, Xiang Yaping, Gao Lihua, Huang Jinhua
Department of Dermatology, Third Xiangya Hospital, Central South University, Changsha 410013, China.
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2018 Feb 28;43(2):124-130. doi: 10.11817/j.issn.1672-7347.2018.02.003.
To investigate associations of interleukin-31 (IL-31) and pruritus in atopic dermatitis (AD) with Meta-analysis. Methods: Materials were extracted from the citations listed in the following databases: PubMed, Science Direct, Web of Science and Cochrane. Key search terms included: atopic dermatitis, pruritus, and IL-31. The Meta-analysis was used to analyze the correlation between pruritws in AD and IL-31 expression level. Results: The Meta-analysis showed that serum IL-31 levels were higher in AD patients than those in the healthy controls. The levels of IL-31 were higher in severe AD patients than those in the mild and moderate AD patients. Moreover, a positive correlation between serum IL-31 levels and severity of pruritus was identified. Conclusion: Increased serum levels of IL-31 generally exist in the AD patients, and it may accelerate the pruritus in the AD patients.
采用Meta分析探讨特应性皮炎（AD）中白细胞介素-31（IL-31）与瘙痒的相关性。方法：从以下数据库列出的文献中提取资料：PubMed、Science Direct、Web of Science和Cochrane。关键检索词包括：特应性皮炎、瘙痒和IL-31。采用Meta分析分析AD患者瘙痒与IL-31表达水平之间的相关性。结果：Meta分析显示，AD患者血清IL-31水平高于健康对照者。重度AD患者的IL-31水平高于轻度和中度AD患者。此外，血清IL-31水平与瘙痒严重程度之间存在正相关。结论：AD患者普遍存在血清IL-31水平升高的情况，它可能会加重AD患者的瘙痒。
