Piroozmand Ahmad, Soltani Babak, Razavizadeh Mohsen, Matini Amir Hasan, Moosavi Gholam Abbas, Salehi Mohammad, Soltani Siamak
Ph.D. of Virology, Associate Professor, Department of Microbiology, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, Iran.
Autoimmune Diseases Research Center, Kashan University of Medical Sciences, Kashan, Iran.
Electron Physician. 2017 Dec 25;9(12):6111-6119. doi: 10.19082/6111. eCollection 2017 Dec.
Triggering receptor expressed on myeloid cells (TREM-1) is a receptor on phagocytes that is triggered by infectious agents. The soluble form of it (sTREM-1) can be elevated in gastric juice by () infection of gastric mucosa. The aim of this study was to compare the diagnostic values of sTREM-1 and C-reactive protein (CRP) for detection of infection in gastric mucosa.
In this diagnostic accuracy study on cases who underwent endoscopy from March 2015 to July 2016 in Shahid Beheshti Hospital, Kashan, Iran, gastric juice sTREM-1 and CRP concentrations were measured by enzyme-linked immunosorbent assays (ELISA) and their diagnostic values were compared to detect infection. Gold standard test was histopathology. Data were entered into SPSS software version 16. Statistical analysis was made by Kolmogorov-Smirnov, Chi-square, Independent-samples t-test, Kruskal-Wallis, Mann-Whitney U, Pearson product-moment correlation, Receiver operating characteristic curve (ROC), Brier score, Nagelkerke R square and scaled reliability test.
Of a total of 160 cases, 81 (50.6%) were -positive based on pathology. The level of sTREM-1 in -positive patients was significantly higher than -negative patients (p=0.000), but no significant difference between CRP concentrations was shown between groups (p=0.7). Sensitivity, specificity, positive likelihood ratio, negative likelihood ratio and accuracy of sTREM-1 were 82%, 75%, 3.3, 0.25, 78% and for CRP were 62%, 40%, 1.02, 0.98, 51% respectively for diagnosis of infection. True positive and negative rates were 66 (81.5%) and 59 (74.7%) for sTREM-1 and 50 (61.7%) and 31 (39.2%) for CRP. The levels of sTREM-1 and CRP were not significantly different between endoscopic finding groups (p=0.97, p=0.2 respectively).
Despite CRP, sTREM-1 was a relatively acceptable indicator of infection of gastric mucosa.
髓系细胞触发受体-1（TREM-1）是吞噬细胞上一种由感染因子触发的受体。其可溶性形式（sTREM-1）可因胃黏膜的（）感染而在胃液中升高。本研究旨在比较sTREM-1和C反应蛋白（CRP）对检测胃黏膜感染的诊断价值。
在伊朗卡尚市沙希德·贝赫什提医院对2015年3月至2016年7月接受内镜检查的病例进行的这项诊断准确性研究中，采用酶联免疫吸附测定法（ELISA）测量胃液中sTREM-1和CRP浓度，并比较它们对检测感染的诊断价值。金标准检测为组织病理学检查。数据录入SPSS 16软件。采用柯尔莫哥洛夫-斯米尔诺夫检验、卡方检验、独立样本t检验、克鲁斯卡尔-沃利斯检验、曼-惠特尼U检验、皮尔逊积矩相关分析、受试者工作特征曲线（ROC）、布里尔评分、纳格尔克R方和标度可靠性检验进行统计分析。
总共160例病例中，81例（50.6%）病理检查为阳性。阳性患者的sTREM-1水平显著高于阴性患者（p = 0.000），但两组之间CRP浓度无显著差异（p = 0.7）。sTREM-1诊断感染的敏感性、特异性、阳性似然比、阴性似然比和准确性分别为82%、75%、3.3、0.25、78%，CRP分别为62%、40%、1.02、0.98、51%。sTREM-1的真阳性和真阴性率分别为66例（81.5%）和59例（74.7%），CRP分别为50例（61.7%）和31例（39.2%）。内镜检查结果组之间sTREM-1和CRP水平无显著差异（分别为p = 0.97，p = 0.2）。
与CRP不同，sTREM-1是胃黏膜感染的一个相对可接受的指标。
