Institute of Organic and Analytical Chemistry (ICOA), University of Orleans, UMR-CNRS 7311, BP 6759 F-45067 Orleans CEDEX 2, France.
Institute of Molecular Chemistry and Materials of Orsay, UMR CNRS 8182, University of Paris-Sud, Building 420, 91400 Orsay, France.
Molecules. 2018 Mar 18;23(3):684. doi: 10.3390/molecules23030684.
A simple and efficient methodology for the nucleophilic aromatic substitution of nitrogen-containing fused heterocycles with interesting biological activities has been developed in an environmentally sound manner using polyethylene glycol (PEG-400) as the solvent, leading to the expected compounds in excellent yields in only five minutes.
已开发出一种简单有效的方法，通过使用环境友好的聚乙二醇（PEG-400）作为溶剂，对具有有趣生物活性的含氮稠合杂环进行亲核芳香取代，仅需五分钟即可以优异的收率得到预期化合物。
