Division of Cardiology, Ulsan University Hospital, University of Ulsan College of Medicine, 877 Bangeojinsunhwando-ro, Dong-gu, Ulsan, 44033, Republic of Korea.
Yonsei Cardiovascular Center, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul, 120-752, Republic of Korea.
Lipids Health Dis. 2018 Nov 24;17(1):268. doi: 10.1186/s12944-018-0914-2.
Insulin resistance (IR) is an important risk factor for subclinical atherosclerosis. This study evaluated the relationship between the triglyceride glucose (TyG) index, which is a simple and reliable surrogate marker for IR, and arterial stiffness.
This study included 2560 Korean subjects without a previous history of coronary artery disease, stroke, and malignancies who participated in a community-based cohort study. Arterial stiffness was measured using the brachial-ankle pulse wave velocity (baPWV).
All participants were stratified into four groups based on the quartile of the TyG index. The prevalence of metabolic syndrome and diabetes significantly increased with increasing TyG index quartile. The mean baPWV was significantly different among all groups (group I [lowest]: 1421 ± 242 vs. group II: 1480 ± 244 vs. group III: 1534 ± 260 vs. group IV [highest]: 1575 ± 279 cm/s; p < 0.001). The TyG index values were correlated with baPWV (r = 0.224, p < 0.001). Multiple regression analysis showed that age (β = 0.410), male gender (β = 0.051), increased blood pressure (β = 0.266), and TyG index (β = 0.158) were associated with baPWV (p < 0.05, respectively). TyG index was independently related to baPWV in both non-diabetics and diabetics.
The TyG index is independently associated with arterial stiffness in a relatively healthy Korean population.
胰岛素抵抗（IR）是亚临床动脉粥样硬化的一个重要危险因素。本研究评估了甘油三酯-葡萄糖（TyG）指数（一种简单可靠的 IR 替代标志物）与动脉僵硬度之间的关系。
本研究纳入了 2560 名韩国受试者，他们没有冠心病、中风和恶性肿瘤的既往病史，参加了一项基于社区的队列研究。使用肱踝脉搏波速度（baPWV）测量动脉僵硬度。
所有参与者均根据 TyG 指数四分位值分为四组。随着 TyG 指数四分位值的升高，代谢综合征和糖尿病的患病率显著增加。所有组之间的平均 baPWV 差异均有统计学意义（第 I 组[最低]：1421±242 比第 II 组：1480±244 比第 III 组：1534±260 比第 IV 组[最高]：1575±279 cm/s；p<0.001）。TyG 指数值与 baPWV 相关（r=0.224，p<0.001）。多元回归分析显示，年龄（β=0.410）、男性（β=0.051）、血压升高（β=0.266）和 TyG 指数（β=0.158）与 baPWV 相关（p<0.05）。在非糖尿病患者和糖尿病患者中，TyG 指数与 baPWV 均独立相关。
在相对健康的韩国人群中，TyG 指数与动脉僵硬度独立相关。
