Flachskampf Frank A, Nihoyannopoulos Petros
Department of Medical Sciences, Clinical Physiology and Cardiology, Akademiska, Uppsala University, Uppsala, Sweden.
Imperial College London, NHLI, Hammersmith Hospital, London, UK.
Echo Res Pract. 2018 Jun 1;5(2):R17-R21. doi: 10.1530/ERP-17-0082.
Normal values provide the background for interpretation of quantitative imaging data and thus are essential information for daily routine. Nevertheless, the ways how normal values are obtained, presented and interpreted, often do not receive the attention they deserve. We review the concepts of normalcy, the implications of typical normal ranges including the types of distribution of normal data, the possibilities to index for confounding biological factors like body surface area and the limitations of the very concept of normal values, demonstrating that there are no easy statistical solutions for difficult clinical problems.
正常值为定量成像数据的解读提供了背景，因此是日常工作中必不可少的信息。然而，获取、呈现和解释正常值的方式往往没有得到应有的关注。我们回顾了正常状态的概念、典型正常范围的含义，包括正常数据的分布类型、针对诸如体表面积等混杂生物因素进行指数化的可能性以及正常值这一概念本身的局限性，表明对于棘手的临床问题不存在简单的统计学解决方案。
