Ojha Utkarsh
Faculty of Medicine, Imperial College School of Medicine, Imperial College London, London, UK.
Diabetes Metab Syndr Obes. 2018 Mar 9;11:45-51. doi: 10.2147/DMSO.S156597. eCollection 2018.
Obesity is a major global health issue. High-protein diets have been shown to be associated with weight loss and satiety. The precise mechanism by which protein-rich diets promote weight loss remains unclear. Evidence suggests amino acids, formed as a consequence of protein digestion, are sensed by specific receptors on L-cells in the gastrointestinal (GI) tract. These L-cells respond by secreting gut hormones that subsequently induce satiety. In recent years, the calcium-sensing receptor has been identified in several cells of the GI tract, including L-cells, and suggested to sense specific amino acids. This review evaluates the evidence for protein-rich diets in inducing weight loss and how the calcium-sensing receptor may be implicated in this phenomenon. Commandeering the mechanisms by which elements of a protein-rich diet suppress appetite may provide another successful avenue for developing anti-obesity drugs.
肥胖是一个重大的全球健康问题。高蛋白饮食已被证明与体重减轻和饱腹感有关。富含蛋白质的饮食促进体重减轻的确切机制尚不清楚。有证据表明，蛋白质消化产生的氨基酸可被胃肠道（GI）中L细胞上的特定受体感知。这些L细胞通过分泌肠道激素做出反应，随后诱导饱腹感。近年来，已在包括L细胞在内的胃肠道多种细胞中鉴定出钙敏感受体，并表明其可感知特定氨基酸。本综述评估了高蛋白饮食诱导体重减轻的证据，以及钙敏感受体可能如何与这一现象相关。掌握富含蛋白质饮食的成分抑制食欲的机制，可能为开发抗肥胖药物提供另一条成功途径。
