Department of Nutrition, Harvard T.H. Chan School of Public Health, 655 Huntington Avenue, Build II Floor 3, Boston, MA, 02115, USA.
Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, USA.
Curr Atheroscler Rep. 2018 Mar 21;20(5):24. doi: 10.1007/s11883-018-0724-z.
To examine recent literature on dairy products, dairy fatty acids, and cardiometabolic disease. Primary questions of interest include what unique challenges researchers face when investigating dairy products/biomarkers, whether one should consume dairy to reduce disease risk, whether dairy fatty acids may be beneficial for health, and whether one should prefer low- or high-fat dairy products.
Dairy composes about 10% of the calories in a typical American diet, about half of that coming from fluid milk, half coming from cheese, and small amounts from yogurt. Most meta-analyses report no or weak inverse association between dairy intake with cardiovascular disease and related intermediate outcomes. There is some suggestion that dairy consumption was inversely associated with stroke incidence and yogurt consumption was associated with lower risk of type 2 diabetes. Odd chain fatty acids (OCFAs) found primarily in dairy (15:0 and 17:0) appear to be inversely associated with cardiometabolic risk, but causation is uncertain. Substitution analyses based on prospective cohorts suggested that replacing dairy fat with vegetable fat or polyunsaturated fat was associated with significantly lower risk of cardiovascular disease. Current evidence suggests null or weak inverse association between consumption of dairy products and risk of cardiovascular disease. However, replacing dairy fat with polyunsaturated fat, especially from plant-based foods, may confer health benefits. More research is needed to examine health effects of different types of dairy products in diverse populations.
研究乳制品、乳脂肪酸与心血管代谢疾病的最新文献。主要关注的问题包括:研究乳制品/生物标志物时,研究人员面临哪些独特的挑战;为降低疾病风险是否应摄入乳制品;乳脂肪酸是否对健康有益;以及是否应选择低脂或高脂乳制品。
乳制品约占典型美国饮食中热量的 10%,其中约一半来自液态奶,一半来自奶酪,还有少量来自酸奶。大多数荟萃分析报告显示,乳制品摄入量与心血管疾病及相关中间结果之间无显著负相关或仅有微弱负相关。有一些证据表明,乳制品摄入与中风发病率呈负相关,酸奶摄入与 2 型糖尿病风险降低相关。主要存在于乳制品中的奇数链脂肪酸(15:0 和 17:0)与心血管代谢风险呈负相关,但因果关系尚不确定。基于前瞻性队列的替代分析表明,用植物脂肪或多不饱和脂肪替代乳制品脂肪与心血管疾病风险显著降低相关。目前的证据表明,乳制品消费与心血管疾病风险之间呈微弱负相关或无相关性。然而,用多不饱和脂肪替代乳制品脂肪,尤其是来自植物性食物的多不饱和脂肪,可能带来健康益处。需要更多的研究来在不同人群中检验不同类型乳制品的健康效应。