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本文引用的文献

1
Dietary Fats and Cardiovascular Disease: A Presidential Advisory From the American Heart Association.膳食脂肪与心血管疾病:美国心脏协会的总统顾问报告。
Circulation. 2017 Jul 18;136(3):e1-e23. doi: 10.1161/CIR.0000000000000510. Epub 2017 Jun 15.
2
Odd-chain fatty acids as a biomarker for dietary fiber intake: a novel pathway for endogenous production from propionate.奇数链脂肪酸作为膳食纤维摄入量的生物标志物:丙酸内源性产生的新途径。
Am J Clin Nutr. 2017 Jun;105(6):1544-1551. doi: 10.3945/ajcn.117.152702. Epub 2017 Apr 19.
3
Milk and dairy consumption and risk of cardiovascular diseases and all-cause mortality: dose-response meta-analysis of prospective cohort studies.牛奶及乳制品的摄入量与心血管疾病风险及全因死亡率:前瞻性队列研究的剂量反应荟萃分析
Eur J Epidemiol. 2017 Apr;32(4):269-287. doi: 10.1007/s10654-017-0243-1. Epub 2017 Apr 3.
4
Dairy Food Intake and All-Cause, Cardiovascular Disease, and Cancer Mortality: The Golestan Cohort Study.乳制品摄入量与全因、心血管疾病及癌症死亡率:戈勒斯坦队列研究
Am J Epidemiol. 2017 Apr 15;185(8):697-711. doi: 10.1093/aje/kww139.
5
Odd Chain Fatty Acids; New Insights of the Relationship Between the Gut Microbiota, Dietary Intake, Biosynthesis and Glucose Intolerance.奇数链脂肪酸;肠道微生物群、饮食摄入、生物合成与葡萄糖不耐受关系的新见解。
Sci Rep. 2017 Mar 23;7:44845. doi: 10.1038/srep44845.
6
Dairy consumption, systolic blood pressure, and risk of hypertension: Mendelian randomization study.乳制品消费、收缩压与高血压风险:孟德尔随机化研究
BMJ. 2017 Mar 16;356:j1000. doi: 10.1136/bmj.j1000.
7
Biomarkers of dairy fat intake and risk of cardiovascular disease: A systematic review and meta analysis of prospective studies.乳制品脂肪摄入量与心血管疾病风险的生物标志物:前瞻性研究的系统评价和荟萃分析。
Crit Rev Food Sci Nutr. 2018 May 3;58(7):1122-1130. doi: 10.1080/10408398.2016.1242114. Epub 2017 Jul 5.
8
Milk fat biomarkers and cardiometabolic disease.乳脂肪生物标志物与心脏代谢疾病
Curr Opin Lipidol. 2017 Feb;28(1):46-51. doi: 10.1097/MOL.0000000000000381.
9
Dairy fat and risk of cardiovascular disease in 3 cohorts of US adults.美国成年人3个队列中的乳脂肪与心血管疾病风险
Am J Clin Nutr. 2016 Nov;104(5):1209-1217. doi: 10.3945/ajcn.116.134460. Epub 2016 Aug 24.
10
Cheese consumption and risk of cardiovascular disease: a meta-analysis of prospective studies.奶酪消费与心血管疾病风险:前瞻性研究的荟萃分析。
Eur J Nutr. 2017 Dec;56(8):2565-2575. doi: 10.1007/s00394-016-1292-z. Epub 2016 Aug 12.

乳制品、乳脂肪酸与心血管代谢疾病的预防:近期证据回顾。

Dairy Products, Dairy Fatty Acids, and the Prevention of Cardiometabolic Disease: a Review of Recent Evidence.

机构信息

Department of Nutrition, Harvard T.H. Chan School of Public Health, 655 Huntington Avenue, Build II Floor 3, Boston, MA, 02115, USA.

Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, USA.

出版信息

Curr Atheroscler Rep. 2018 Mar 21;20(5):24. doi: 10.1007/s11883-018-0724-z.

DOI:10.1007/s11883-018-0724-z
PMID:29564646
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5990967/
Abstract

PURPOSE OF REVIEW

To examine recent literature on dairy products, dairy fatty acids, and cardiometabolic disease. Primary questions of interest include what unique challenges researchers face when investigating dairy products/biomarkers, whether one should consume dairy to reduce disease risk, whether dairy fatty acids may be beneficial for health, and whether one should prefer low- or high-fat dairy products.

RECENT FINDINGS

Dairy composes about 10% of the calories in a typical American diet, about half of that coming from fluid milk, half coming from cheese, and small amounts from yogurt. Most meta-analyses report no or weak inverse association between dairy intake with cardiovascular disease and related intermediate outcomes. There is some suggestion that dairy consumption was inversely associated with stroke incidence and yogurt consumption was associated with lower risk of type 2 diabetes. Odd chain fatty acids (OCFAs) found primarily in dairy (15:0 and 17:0) appear to be inversely associated with cardiometabolic risk, but causation is uncertain. Substitution analyses based on prospective cohorts suggested that replacing dairy fat with vegetable fat or polyunsaturated fat was associated with significantly lower risk of cardiovascular disease. Current evidence suggests null or weak inverse association between consumption of dairy products and risk of cardiovascular disease. However, replacing dairy fat with polyunsaturated fat, especially from plant-based foods, may confer health benefits. More research is needed to examine health effects of different types of dairy products in diverse populations.

摘要

审查目的

研究乳制品、乳脂肪酸与心血管代谢疾病的最新文献。主要关注的问题包括:研究乳制品/生物标志物时,研究人员面临哪些独特的挑战;为降低疾病风险是否应摄入乳制品;乳脂肪酸是否对健康有益;以及是否应选择低脂或高脂乳制品。

最新发现

乳制品约占典型美国饮食中热量的 10%,其中约一半来自液态奶,一半来自奶酪,还有少量来自酸奶。大多数荟萃分析报告显示,乳制品摄入量与心血管疾病及相关中间结果之间无显著负相关或仅有微弱负相关。有一些证据表明,乳制品摄入与中风发病率呈负相关,酸奶摄入与 2 型糖尿病风险降低相关。主要存在于乳制品中的奇数链脂肪酸(15:0 和 17:0)与心血管代谢风险呈负相关,但因果关系尚不确定。基于前瞻性队列的替代分析表明,用植物脂肪或多不饱和脂肪替代乳制品脂肪与心血管疾病风险显著降低相关。目前的证据表明,乳制品消费与心血管疾病风险之间呈微弱负相关或无相关性。然而,用多不饱和脂肪替代乳制品脂肪,尤其是来自植物性食物的多不饱和脂肪,可能带来健康益处。需要更多的研究来在不同人群中检验不同类型乳制品的健康效应。