Cannizzaro Maria V, Dattola Annunziata, Garofalo Virginia, Del Duca Ester, Bianchi Luca
Department of Dermatology and Venereology, Tor Vergata University of Rome, Rome, Italy -
Department of Dermatology and Venereology, Tor Vergata University of Rome, Rome, Italy.
G Ital Dermatol Venereol. 2018 Apr;153(2):161-164. doi: 10.23736/S0392-0488.17.05742-X.
Acne vulgaris is a chronic inflammatory skin disease that manifests as open and closed comedones as well as inflammatory papules, pustules, and nodules localized on face and trunk. Oral isotretinoin demonstrated to be effective in controlling seborrhea, inflammation, Propionibacterium Acnes hyperproliferation and reducing scarring, nevertheless muco-cutaneous side effects, particularly dryness, itching, bruising are commonly seen in patients under treatment with isotretinoin reducing the compliance to the treatment. We conducted a randomized controlled trial to evaluate the efficacy of a cream compound formulated in order to reduce the oral isotretinoin side effects (redness, dryness, itching) in patients affected by severe acne of the face.
Twenty-seven patients undergoing treatment with 0.5-1 mg/kg/day for papulo-pustular or nodulo-cystic acne were randomized to additionally receive a cream composed of 8% omega-ceramides, hydrophilic sugars, 5% niacinamide applied twice daily (group A) or placebo cream (group B) applied 2 times per day.
During the whole treatment period and after 6 months of treatment, patients in the group A showed a greater reduction of dryness, itching and redness compared to the group receiving the placebo cream.
The cream formulated with 8% omega-ceramides, hydrophilic sugars, 5% niacinamide was effective in reducing xerosis and skin irritation, and was also successful in improving the patients' adherence to the oral isotretinoin treatment.
寻常痤疮是一种慢性炎症性皮肤病，表现为开放性和闭合性粉刺以及位于面部和躯干的炎性丘疹、脓疱和结节。口服异维A酸已被证明在控制皮脂溢出、炎症、痤疮丙酸杆菌过度增殖以及减少瘢痕形成方面有效，然而，在接受异维A酸治疗的患者中，黏膜皮肤副作用，尤其是干燥、瘙痒、瘀伤较为常见，这降低了患者对治疗的依从性。我们进行了一项随机对照试验，以评估一种配制的乳膏在减少面部重度痤疮患者口服异维A酸副作用（发红、干燥、瘙痒）方面的疗效。
27例接受0.5 - 1mg/kg/天治疗丘疹脓疱型或结节囊肿型痤疮的患者被随机分组，额外接受一种由8%欧米伽神经酰胺、亲水性糖、5%烟酰胺组成的乳膏，每天涂抹两次（A组），或每天涂抹两次安慰剂乳膏（B组）。
在整个治疗期间及治疗6个月后，A组患者在干燥、瘙痒和发红方面的减轻程度高于接受安慰剂乳膏的组。
由8%欧米伽神经酰胺、亲水性糖、5%烟酰胺配制的乳膏在减轻皮肤干燥和刺激方面有效，并且在提高患者对口服异维A酸治疗的依从性方面也取得了成功。
