Department of Respiratory Medicine, No. 92 Hospital of PLA, Nanping, Fujian 341000, P.R. China.
Department of Hematology, No. 463 Hospital of PLA, Shenyang, Liaoning 110840, P.R. China.
Oncol Rep. 2018 May;39(5):2342-2350. doi: 10.3892/or.2018.6327. Epub 2018 Mar 20.
The incidence of lung cancer in China increases annually, and effective targets for the diagnosis and treatment of lung cancer are urgently needed. miRNAs are currently considered to be involved in the regulation of tumor development and growth. miR‑24 has been found to contribute to the development of several tumors. Menin is a key tumor suppressor gene, and its expression is generally low in lung cancer. The effects of miR‑24 on the biological behavior of lung cancer cells were detected by MTT and Transwell assays. In the present study, miR‑24 was found to be associated with menin, affecting the activity of the SMAD3 pathway in lung cancer by inhibiting menin expression. miR‑24 may promote the growth and metastasis and inhibit the apoptosis of lung cancer cells by targeting menin. Therefore, the aim of the present study was to provide a new theoretical basis for the targeted therapy of lung cancer.
中国的肺癌发病率逐年上升，迫切需要有效的肺癌诊断和治疗靶点。miRNAs 目前被认为参与肿瘤的发生和生长的调控。miR-24 已被发现与多种肿瘤的发生有关。Menin 是一种关键的抑癌基因，其在肺癌中的表达通常较低。通过 MTT 和 Transwell 检测 miR-24 对肺癌细胞生物学行为的影响。本研究发现 miR-24 与 menin 相关，通过抑制 menin 表达影响肺癌中 SMAD3 通路的活性。miR-24 可能通过靶向 menin 促进肺癌细胞的生长和转移，抑制其凋亡。因此，本研究旨在为肺癌的靶向治疗提供新的理论依据。
