Department of Internal Medicine, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, Korea.
Department of Family Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
PLoS One. 2018 Mar 22;13(3):e0193191. doi: 10.1371/journal.pone.0193191. eCollection 2018.
No studies have reported the relationship between nonalcoholic fatty liver disease (NAFLD) and concurrent cerebral artery and coronary artery atherosclerosis simultaneously. We aimed at determining whether NAFLD, as assessed by ultrasound, is associated with subclinical cerebro-cardio vascular atherosclerosis (CCVA) by multidetector-row computed tomography (MDCT), and high resolution-magnetic resonance angiography (HR-MRA). This cross-sectional study included men in the general Korean population aged 20-70 years.
A total of 1,652 men participated in the study (normal, n = 835; mild-to-moderate NAFLD, n = 512; severe NAFLD, n = 305). The risk of subclinical CCVA was positively associated with age (odds ratio [OR] 1.068; 1.054-1.081, p < 0.001), body mass index (OR 1.120; 1.08 0-1.162, p < 0.001), hepatic enzyme levels (OR 1.012; 1.001-1.023, p = 0.027; OR 1.006; 1.001-1.012, p = 0.036), fasting glucose (OR 1.021; 1.015-1.027, p < 0.001), triglycerides (OR 1.002; 1.000-1.003, p = 0.016), hypertension (OR 2.836; 2.268-3.546, p < 0.001), and diabetes (OR 2.911; 2.137-3.964, p < 0.001). Also, high-density lipoprotein cholesterol was inversely associated with subclinical CCVA (OR 0.974; 0.965-0.982, p < 0.001). Compared with normal controls, the OR for subclinical CCVA after full adjustment was 1.46 in the mild-to-moderate NAFLD group (95% confidence interval [CI]: 1.10 to 1.93) and 2.04 in the severe NAFLD group (95% CI: 1.44 to 2.89).
Our data show that NAFLD is common among Korean men, and NAFLD severity on ultrasonography is associated with subclinical CCVA, as assessed by MDCT, and HR-MRA.
目前尚无研究报道非酒精性脂肪性肝病（NAFLD）与同时存在的脑动脉和冠状动脉粥样硬化之间的关系。我们旨在通过多排螺旋 CT（MDCT）和高分辨率磁共振血管造影（HR-MRA）确定超声评估的 NAFLD 是否与亚临床心脑血管动脉粥样硬化（CCVA）相关。本横断面研究纳入了年龄在 20-70 岁的一般韩国人群中的男性。
共有 1652 名男性参与了这项研究（正常组，n=835；轻度至中度 NAFLD 组，n=512；重度 NAFLD 组，n=305）。亚临床 CCVA 的风险与年龄呈正相关（比值比 [OR] 1.068；1.054-1.081，p<0.001）、体重指数（OR 1.120；1.080-1.162，p<0.001）、肝酶水平（OR 1.012；1.001-1.023，p=0.027；OR 1.006；1.001-1.012，p=0.036）、空腹血糖（OR 1.021；1.015-1.027，p<0.001）、甘油三酯（OR 1.002；1.000-1.003，p=0.016）、高血压（OR 2.836；2.268-3.546，p<0.001）和糖尿病（OR 2.911；2.137-3.964，p<0.001）。此外，高密度脂蛋白胆固醇与亚临床 CCVA 呈负相关（OR 0.974；0.965-0.982，p<0.001）。与正常对照组相比，轻度至中度 NAFLD 组亚临床 CCVA 的调整后比值比为 1.46（95%置信区间 [CI]：1.10-1.93），重度 NAFLD 组为 2.04（95%CI：1.44-2.89）。
我们的数据表明，NAFLD 在韩国男性中很常见，超声评估的 NAFLD 严重程度与 MDCT 和 HR-MRA 评估的亚临床 CCVA 相关。
