Băloşeanu Cristina L, Streba C T, Vere C C, Comănescu Violeta, Rogoveanu I
University of Medicine and Pharmacy of Craiova, Craiova, Romania.
Rom J Morphol Embryol. 2012;53(3):609-14.
The prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing all over the world. NAFLD has been demonstrated to be associated with carotid artery atherosclerosis, evaluated using the intima-media thickness (IMT). In this article, we focused on the association between NAFLD, carotid parameters such as: intima-media thickness (IMT), pulsatility index (PI) and resistivity index (RI) as markers of subclinical atherosclerosis and the presence of retinal vascular disorders.
We compared carotid IMT, pulsatility and resistivity index evaluated by ultrasonography, in 10 patients with histological-proven NAFLD and retinal vascular changes (retinophotographies).
The degree of hepatic steatosis, necroinflammation and fibrosis in NAFLD patients was strongly associated with the value of carotid IMT and also with PI and RI. Moreover, there seems to be a connection between the degree of NAFDL and the retinal vascular changes in patients with carotid atherosclerosis.
These results suggest that the severity of liver histopathological lesions among NAFLD patients is strongly associated with carotid parameters: IMT, IP, IR and also with retinal vascular changes. Further controlled studies are needed to confirm the results.
非酒精性脂肪性肝病（NAFLD）在全球的患病率正在上升。NAFLD已被证明与使用内膜中层厚度（IMT）评估的颈动脉粥样硬化有关。在本文中，我们重点关注NAFLD、颈动脉参数（如内膜中层厚度（IMT）、搏动指数（PI）和阻力指数（RI））作为亚临床动脉粥样硬化标志物与视网膜血管疾病存在之间的关联。
我们比较了10例经组织学证实患有NAFLD且有视网膜血管变化（视网膜照片）的患者通过超声检查评估的颈动脉IMT、搏动性和阻力指数。
NAFLD患者的肝脂肪变性、坏死性炎症和纤维化程度与颈动脉IMT值以及PI和RI密切相关。此外，在患有颈动脉粥样硬化的患者中，NAFDL程度与视网膜血管变化之间似乎存在联系。
这些结果表明，NAFLD患者肝脏组织病理学病变的严重程度与颈动脉参数：IMT、IP、IR以及视网膜血管变化密切相关。需要进一步的对照研究来证实这些结果。
