Pannek Jürgen, Kurmann Carmen, Imbach Esther, Amsler Felix, Pannek-Rademacher Susanne
Department of Neuro Urology, Swiss Paraplegic Centre, Nottwil, Switzerland.
Medical Laboratory, Swiss Paraplegic Centre, Nottwil, Switzerland.
Homeopathy. 2018 May;107(2):150-154. doi: 10.1055/s-0038-1637729. Epub 2018 Mar 22.
Recurrent urinary tract infections (UTIs) are one of the most common morbidities in persons with neurogenic lower urinary tract dysfunction (NLUTD). Repetitive antibiotic treatment increases the risk of selecting multi-resistant bacteria. Homeopathic treatment has been reported to be effective in these patients. The mechanism of action, however, has not been clarified. Recently, a direct bactericidal effect of homeopathic remedies was shown. Such an effect is not in accordance with the general principles of homeopathy. To test this paradigm, we assessed the in vitro effects of homeopathic drugs on derived from patients with NLUTD.
bacteria were harvested from 28 consecutive urine cultures. Standard antibiotic resistance testing and simultaneous resistance testing to homeopathic drugs () in high (C30) potency were performed.
No significant inhibitory effect of any of the tested homeopathic drugs on any population could be found, irrespective of their sensitivity to antibiotic treatment.
Based on our results, effects of homeopathic treatment of UTI are not based on direct bactericidal or bacteriostatic effects. These findings are in concordance with the hypothesis that homeopathy is based on host effects: for example, activation of the immune system, rather than effects on pathogens.
复发性尿路感染（UTI）是神经源性下尿路功能障碍（NLUTD）患者中最常见的病症之一。反复使用抗生素治疗会增加选择多重耐药菌的风险。据报道，顺势疗法治疗对这些患者有效。然而，其作用机制尚未阐明。最近，显示了顺势疗法药物的直接杀菌作用。这种作用不符合顺势疗法的一般原则。为了验证这一范例，我们评估了顺势疗法药物对NLUTD患者分离出的细菌的体外作用。
从连续28次尿培养中收集细菌。进行了标准抗生素耐药性测试以及对高（C30）效力顺势疗法药物（）的同步耐药性测试。
无论受试顺势疗法药物对任何细菌群体对抗生素治疗的敏感性如何，均未发现有显著抑制作用。
根据我们的结果，顺势疗法治疗UTI的效果并非基于直接杀菌或抑菌作用。这些发现与顺势疗法基于宿主效应的假设一致：例如，激活免疫系统，而非对病原体的作用。
