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与氯己定相比,阿育吠陀药物治疗慢性牙周炎的疗效:一项随机对照临床研究。

Efficacy of Ayurvedic drugs as compared to chlorhexidine in management of chronic periodontitis: A randomized controlled clinical study.

作者信息

Mittal Neelam, Joshi Vinod Kumar, Srivastava Ratan Kumar, Singh Shri Prakash

机构信息

Conservative Dentistry and Endodontics, Faculty of Dental Sciences, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.

Department of Dravyaguna, Faculty of Ayurveda, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.

出版信息

J Indian Soc Periodontol. 2018 Jan-Feb;22(1):28-33. doi: 10.4103/jisp.jisp_315_16.

Abstract

BACKGROUND

In India, Ayurveda is considered to be more effective and cheaper than modern medicine. Ayurvedic literature shows its use in treating oral diseases also. However, their effectiveness, in comparison with the allopathic mode of management, has not been assessed previously. The aim of this randomized controlled clinical trial was to compare the efficacy of ayurvedic drugs over chlorhexidine in treating chronic periodontitis.

MATERIALS AND METHODS

Four hundred and eight participants, in the age group 20-49 years, suffering from mild-to-moderate chronic periodontitis were included in this study. Community periodontal index for treatment needs (CPITN) score was recorded, and oral prophylaxis was done for each patient. They were then randomly divided into 6 groups: control group (I), chlorhexidine (II), Khadiradi vati (III), Dashansanskar churana (IV), Neem (V), and Apamarga (VI); based on the drugs used by patients for the maintenance of oral hygiene after oral prophylaxis. Patients were recalled at 1 week, 1 month, and 3 months after oral prophylaxis. CPITN score was re-recorded for each patient at each follow-up. Reduction in CPITN score indicated improvement in the periodontal health. Observations were statistically analyzed using univariate ANOVA and value was set at <0.5.

RESULTS

Improvement in CPITN scores in 6 groups was as follows: I - 42.0%, II - 76.37%, III - 82.03%, IV - 83.46%, V - 78.8%, and VI - 29.9%. Higher mean percentage improvement was seen when patients used these drugs for 3 months as compared to 1 month.

CONCLUSION

Dashansanskar churana and Khadiradi vati showed better results than chlorhexidine and were found to be superior in managing mild-to-moderate cases of chronic periodontitis.

摘要

背景

在印度,阿育吠陀医学被认为比现代医学更有效且成本更低。阿育吠陀医学文献显示其也可用于治疗口腔疾病。然而,与对抗疗法的治疗方式相比,其有效性此前尚未得到评估。这项随机对照临床试验的目的是比较阿育吠陀药物与洗必泰在治疗慢性牙周炎方面的疗效。

材料与方法

本研究纳入了408名年龄在20至49岁之间、患有轻至中度慢性牙周炎的参与者。记录治疗需要社区牙周指数(CPITN)得分,并对每位患者进行口腔预防治疗。然后将他们随机分为6组:对照组(I)、洗必泰组(II)、诃梨勒丸组(III)、大山三善散组(IV)、印楝组(V)和苘麻组(VI);分组依据是患者在口腔预防治疗后用于维持口腔卫生的药物。在口腔预防治疗后1周、1个月和3个月对患者进行复诊。每次复诊时为每位患者重新记录CPITN得分。CPITN得分的降低表明牙周健康状况有所改善。使用单因素方差分析对观察结果进行统计学分析,设定P值<0.5。

结果

6组CPITN得分的改善情况如下:I组 - 42.0%,II组 - 76.37%,III组 - 82.03%,IV组 - 83.46%,V组 - 78.8%,VI组 - 29.9%。与使用1个月相比,患者使用这些药物3个月时平均改善百分比更高。

结论

大山三善散和诃梨勒丸比洗必泰显示出更好的效果,且在治疗轻至中度慢性牙周炎病例方面被发现更具优势。

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