Advani Rashmi, Arad Danit
Department of Internal Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, 10467, USA.
F1000Res. 2018 Jan 11;7:46. doi: 10.12688/f1000research.13513.1. eCollection 2018.
Palm and sole skin eruptions have a broad differential diagnosis. It is particularly important to recognize common causes as well as their association with certain chemotherapy regimens such as Capecitabine. A 79-year-old woman presented with a painful rash on her hands and feet for 1 week. She had metastatic colon cancer and was in her third week of treatment with capecitabine. Her diagnosis was a medication side-effect from chemotherapy. Capecitabine was stopped and she had some clinical improvement over the next two days. She was discharged with oncology follow up for resumption of Capecitabine at a lower dose with improvement in her rash 3 weeks later. Skin rashes are a commonly encountered complaint in patients in the inpatient and outpatient setting. It is important to maintain a broad differential diagnosis in those with rashes of the palmoplantar surfaces of the hands and feet. Recognizing skin changes as a possible manifestation of underlying malignancy or a medication side-effect is key in appropriate diagnosis and treatment.
手掌和足底皮肤疹有广泛的鉴别诊断。识别常见病因以及它们与某些化疗方案（如卡培他滨）的关联尤为重要。一名79岁女性因手脚疼痛性皮疹就诊1周。她患有转移性结肠癌，正处于卡培他滨治疗的第三周。她的诊断为化疗药物副作用。停用卡培他滨后，接下来两天她的症状有了一些改善。她出院时接受肿瘤学随访，3周后以较低剂量恢复使用卡培他滨，皮疹有所改善。皮肤疹是住院和门诊患者常见的主诉。对于手脚掌跖表面有皮疹的患者，保持广泛的鉴别诊断很重要。认识到皮肤变化可能是潜在恶性肿瘤或药物副作用的表现是正确诊断和治疗的关键。
