State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China.
State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China.
J Mech Behav Biomed Mater. 2018 Jun;82:61-69. doi: 10.1016/j.jmbbm.2018.03.002. Epub 2018 Mar 8.
Mechanically strong dual/multi-stimuli-responsive smart hydrogels have attracted extensive attention in recent years. A novel tough, mechanical strong and biocompatible dual pH- and temperature- responsive poly (N-isopropylacrylamide) /clay (laponite XLG)/carboxymethyl chitosan (CMCTs) /genipin nanocomposite double network hydrogel was synthesized through a facile, one-pot free radical polymerization initiated by the ultraviolet light, using clay and the natural molecular-genipin as the cross-linkers instead of toxic organic molecules. Crucial factors, the content of CMCTs, clay and genipin, for synthesizing the mechanical strong hydrogels were investigated. When the content of CMCTs, clay and genipin were 5 wt%, 33.3 wt% and 0.175 wt%, respectively (to the weight of N-isopropylacrylamide), these prepared hydrogels exhibited a high tensile strength of 137.9 kPa at the failure strain of 446.1%. Furthermore, the relationship between swelling and deswelling rate of the synthesized hydrogels and the above crucial factors were also studied. Besides, the synthesized hydrogels displayed a considerable controlled release property of asprin by tuning their inner crosslink density. Owing to this property, they may have great potential in the drug delivery systems.
近年来，机械强度高的双（多）刺激响应智能水凝胶受到了广泛关注。通过一种简便的、一锅自由基聚合方法，使用粘土和天然分子京尼平作为交联剂（而不是有毒的有机分子），由紫外光引发，合成了一种新型坚韧、机械强度高、生物相容性好的双 pH 和温度响应聚（N-异丙基丙烯酰胺）/粘土（Laponite XLG）/羧甲基壳聚糖（CMCTs）/京尼平纳米复合双网络水凝胶。探讨了合成机械强度高的水凝胶的关键因素，即 CMCTs、粘土和京尼平的含量。当 CMCTs、粘土和京尼平的含量分别为 5wt%、33.3wt%和 0.175wt%（相对于 N-异丙基丙烯酰胺的重量）时，这些制备的水凝胶在 446.1%的断裂应变下表现出 137.9kPa 的高拉伸强度。此外，还研究了合成水凝胶的溶胀和去溶胀速率与上述关键因素之间的关系。此外，通过调节其内部交联密度，合成的水凝胶对阿司匹林表现出相当好的控制释放性能。由于这种特性，它们在药物输送系统中可能具有巨大的潜力。
