Department of Pathobiology, Cleveland Clinic Lerner Research Institute, Cleveland, OH, United States.
Department of Pathobiology, Cleveland Clinic Lerner Research Institute, Cleveland, OH, United States.
Matrix Biol. 2019 May;78-79:314-323. doi: 10.1016/j.matbio.2018.03.011. Epub 2018 Mar 21.
Hyaluronan, a major extracellular matrix component, is an active participant in many disease states, including inflammatory bowel disease (IBD). The synthesis of this dynamic polymer is increased at sites of inflammation. Hyaluronan together with the enzymes responsible for its synthesis, degradation, and its binding proteins, directly modulates the promotion and resolution of disease by controlling recruitment of immune cells, by release of inflammatory cytokines, and by balancing hemostasis. This review discusses the functional significance of hyaluronan in the cells and tissues involved in inflammatory bowel disease pathobiology.
透明质酸是细胞外基质的主要成分之一，是许多疾病状态的积极参与者，包括炎症性肠病（IBD）。这种动态聚合物的合成在炎症部位增加。透明质酸与其合成、降解以及结合蛋白相关的酶一起，通过控制免疫细胞的募集、释放炎症细胞因子以及平衡止血作用，直接调节疾病的促进和消退。本文讨论了透明质酸在涉及炎症性肠病病理生物学的细胞和组织中的功能意义。
