School of Medicinal and Health Products Sciences, Master in Aesthetic Medicine and Therapeutics, University of Camerino, Camerino, Italy.
Biofactors. 2022 Sep;48(5):1027-1035. doi: 10.1002/biof.1881. Epub 2022 Aug 18.
Skin aging is a complex biological process. Skin aspect is considered as a sign of well-being and of beauty. In view of this, noninvasive and/or minimally invasive anti-aging strategies were developed. Adenosine, a well-known nucleoside, may play a role in skin rejuvenation. Adenosine receptors belong to the G protein-coupled receptors superfamily and are divided into four subtypes: A , A , A , and A . The adenosine receptors expressed by skin are mainly the A and A subtypes. In the hypodermis, adenosine through the A receptor stimulates lipogenesis and adipogenesis. In the dermis, adenosine through the A receptor subtype stimulates collagen production. Moreover, the nucleoside increases new DNA synthesis and subsequently protein synthesis in dermal cells. Activation of adenosine receptors by interacting with various skin layers may induce a decrease in the amount of wrinkles, roughness, dryness, and laxity. This article has reviewed the mechanisms through which adenosine modulates biological mechanisms in the skin tissues and the effect of preparations containing adenosine or its derivatives on the skin.
皮肤衰老过程是一个复杂的生物学过程。皮肤状况被认为是健康和美丽的标志。有鉴于此，人们开发了非侵入性和/或微创性抗衰老策略。腺苷是一种众所周知的核苷，可能在皮肤年轻化中发挥作用。腺苷受体属于 G 蛋白偶联受体超家族，分为 A 、A 、A 和 A 四种亚型。皮肤表达的腺苷受体主要是 A 和 A 亚型。在下皮组织中，腺苷通过 A 受体刺激脂肪生成和脂肪形成。在真皮中，腺苷通过 A 受体亚型刺激胶原蛋白生成。此外，核苷增加真皮细胞中新的 DNA 合成，随后增加蛋白质合成。通过与皮肤各层相互作用激活腺苷受体，可能会导致皱纹、粗糙度、干燥和松弛程度减少。本文综述了腺苷调节皮肤组织中生物机制的机制，以及含有腺苷或其衍生物的制剂对皮肤的作用。
