Shen C, Yang L, Miller S L, Oró J
Orig Life Evol Biosph. 1987;17(3-4):295-305. doi: 10.1007/BF02386469.
The prebiotic synthesis of imidazole-4-acetaldehyde and imidazole-4-glycol from erythrose and formamidine has been demonstrated as well as the prebiotic synthesis of imidazole-4-ethanol and imidazole-4-glycol from erythrose, formaldehyde and ammonia. The products were identified by TLC, HPLC, and LC-MS by comparison with authentic samples. The maximum yields of imidazole-4-acetaldehyde, imidazole-4-ethanol, and imidazole-4-glycol obtained in these reactions are 1.6, 5.4, 6.8% respectively, based on the erythrose. Imidazole-4-acetaldehyde would have been converted to histidine on the primitive earth by a Strecker synthesis, and several prebiotic reactions would convert imidazole-4-glycol and imidazole-4-ethanol to imidazole-4-acetaldehyde.
已证实由赤藓糖和甲脒进行的咪唑 - 4 - 乙醛和咪唑 - 4 - 二醇的益生元合成，以及由赤藓糖、甲醛和氨进行的咪唑 - 4 - 乙醇和咪唑 - 4 - 二醇的益生元合成。通过与标准样品比较，利用薄层层析法（TLC）、高效液相色谱法（HPLC）和液相色谱 - 质谱联用仪（LC - MS）对产物进行了鉴定。基于赤藓糖，在这些反应中获得的咪唑 - 4 - 乙醛、咪唑 - 4 - 乙醇和咪唑 - 4 - 二醇的最大产率分别为1.6%、5.4%、6.8%。在原始地球上，咪唑 - 4 - 乙醛会通过斯特雷克合成转化为组氨酸，并且一些益生元反应会将咪唑 - 4 - 二醇和咪唑 - 4 - 乙醇转化为咪唑 - 4 - 乙醛。
