Andisheh-Tadbir Azadeh, Mardani Maryam, Malekzadeh Mahyar, Amirbeigi Tafti Tayebe, Khademi Bijan
Oral and Dental Disease Research Center, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran. Email:
Asian Pac J Cancer Prev. 2018 Mar 27;19(3):689-692. doi: 10.22034/APJCP.2018.19.3.689.
Objective: To identify serum levels of galectin-3 in salivary gland cancer and healthy populations; a prospective analysis was performed on serum specimens from 105 patients with salivary gland cancer and 56 healthy persons. Methods: Enzyme-linked immunosorbent assay (ELISA) was used to measure levels of galectin-3 (GAL-3). Serum levels were compared between patients with salivary gland tumors and healthy control. A total of 105 patients were enrolled in the study (55 men, 50 women). Result: Mean age was 45.5 years. Thirty-nine patients with malignant and 66 cases with benign tumors were compared with 56 healthy participants with a mean age of 51.7. No statistically significant differences were observed when comparing GAL-3 serum levels between malignant and benign salivary gland tumor patients, but a statistically significant difference was found between case and control patients with p-values of 0.02. Serum levels of galectin-3 protein were elevated in patients with salivary gland cancer compared with the healthy population. Conclusion: The difference between benign and malignant tumor patients was significant, but revealed no clinic pathological characteristics in malignant tumors. To the best of the authors’ knowledge, this is the first time a study suggests that GAL-3 serum levels could help clinicians screen for salivary gland cancer.
确定唾液腺癌患者和健康人群的血清半乳糖凝集素-3水平;对105例唾液腺癌患者和56名健康人的血清样本进行了前瞻性分析。方法:采用酶联免疫吸附测定法(ELISA)检测半乳糖凝集素-3(GAL-3)水平。比较唾液腺肿瘤患者和健康对照者的血清水平。共有105例患者纳入研究(55例男性,50例女性)。结果:平均年龄为45.5岁。将39例恶性肿瘤患者和66例良性肿瘤患者与56名平均年龄为51.7岁的健康参与者进行比较。比较恶性和良性唾液腺肿瘤患者的GAL-3血清水平时未观察到统计学上的显著差异,但病例组和对照组之间存在统计学上的显著差异,p值为0.02。与健康人群相比,唾液腺癌患者的半乳糖凝集素-3蛋白血清水平升高。结论:良性和恶性肿瘤患者之间存在显著差异,但在恶性肿瘤中未发现临床病理特征。据作者所知,这是首次有研究表明GAL-3血清水平可帮助临床医生筛查唾液腺癌。