脂肪肝指数与健康受试者脉搏波速度相关：来自 Brisighella 心脏研究的数据。
Fatty liver index is associated to pulse wave velocity in healthy subjects: Data from the Brisighella Heart Study.
机构信息
Atherosclerosis Research Unit, Department of Medical and Surgical Sciences, University of Bologna and Azienda Ospedaliero-Universitaria di Bologna, Policlinico Sant'Orsola Malpighi, Bologna, Italy.
ITEC Unit, Department of Medical and Surgical Sciences, University of Bologna and Azienda Ospedaliero-Universitaria di Bologna, Policlinico Sant'Orsola Malpighi, Bologna, Italy; Research Center for the Study of Hepatitis, Department of Medical and Surgical Sciences, University of Bologna, Italy.
出版信息
Eur J Intern Med. 2018 Jul;53:29-33. doi: 10.1016/j.ejim.2018.03.010. Epub 2018 Mar 24.
BACKGROUND
Non-Alcoholic Fatty Liver Disease (NAFLD) is associated to increased risk of cardiovascular disease. Our aim was to evaluate association of indexes of fatty liver with arterial stiffness (AS).
METHODS
We analyzed data of adult volunteers visited during the last Brisighella survey. We evaluated the Pulse Wave Velocity (PWV) and the following non-invasive indexes of liver steatosis: Fatty Liver Index (FLI), Lipid Accumulation Product (LAP), Hepatic Steatosis Index (HSI). We compared patients according to the risk of Non-Alcoholic Steatohepatitis (NASH): low-risk (BMI < 28 and no diabetes), intermediate-risk (BMI ≥ 28 or diabetes), high-risk (BMI ≥ 28 and diabetes). Multiple Linear Regression analysis was assessed for predictors of AS.
RESULTS
We studied 1731 volunteers. In subjects with low metabolic risk, HSI (RR = 0.138, 95%CI 0.105-0.170, p < 0.001), FLI (RR = 0.024, 95%CI 0.016-0.032, p < 0.001), LAP (RR = 0.014, 95%CI 0.008-0.020, p < 0.001) and Serum Uric Acid (RR = 0.150, 95%CI 0.024-0.275, p = 0.019) were significant predictors of AS. HSI and FLI emerged as predictors of PWV in intermediate risk group (RR = 0.116, 95%CI 0.071-0.160, p < 0.001; RR = 0.010, 95%CI 0.001-0.020, p = 0.041). In volunteers with high risk, FLI and Uric Acid were related to PWV (RR = 0.049, 95%CI 0.011-0.087, p = 0.013; RR = 0.632, 95% CI 0.222-1.041, p = 0.003).
CONCLUSION
Fatty liver indirect indexes were associated to AS in subjects with different metabolic risk profiles.
背景
非酒精性脂肪性肝病（NAFLD）与心血管疾病风险增加相关。我们的目的是评估脂肪肝指标与动脉僵硬度（AS）的相关性。
方法
我们分析了在最近的 Brisighella 调查中接受检查的成年志愿者的数据。我们评估了脉搏波速度（PWV）和以下非侵入性肝脂肪变性指标：脂肪肝指数（FLI）、脂质蓄积产物（LAP）、肝脂肪指数（HSI）。我们根据非酒精性脂肪性肝炎（NASH）的风险对患者进行了比较：低风险（BMI<28 且无糖尿病）、中风险（BMI≥28 或糖尿病）、高风险（BMI≥28 且糖尿病）。使用多元线性回归分析评估 AS 的预测因素。
结果
我们研究了 1731 名志愿者。在代谢风险低的患者中，HSI（RR=0.138，95%CI 0.105-0.170，p<0.001）、FLI（RR=0.024，95%CI 0.016-0.032，p<0.001）、LAP（RR=0.014，95%CI 0.008-0.020，p<0.001）和血清尿酸（RR=0.150，95%CI 0.024-0.275，p=0.019）是 AS 的显著预测因素。HSI 和 FLI 是中风险组 PWV 的预测因素（RR=0.116，95%CI 0.071-0.160，p<0.001；RR=0.010，95%CI 0.001-0.020，p=0.041）。在高风险的志愿者中，FLI 和尿酸与 PWV 相关（RR=0.049，95%CI 0.011-0.087，p=0.013；RR=0.632，95%CI 0.222-1.041，p=0.003）。
结论
在具有不同代谢风险特征的受试者中，脂肪肝间接指标与 AS 相关。
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