Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Ageing Res Rev. 2018 Jul;44:22-32. doi: 10.1016/j.arr.2018.03.006. Epub 2018 Mar 23.
Mitochondria play an essential part in guaranteeing normal cellular physiological functions through providing ATP and participating in diverse processes and signaling pathways. Recently, more and more studies have revealed the vital roles of mitochondria in coping with stressors in the aging process, metabolic disturbances and neurological disorders. Mitochondrial stress responses, including the mitochondrial unfolded protein response (UPR), antioxidant defense, mitochondrial fission, mitochondrial fusion and mitophagy, are induced to maintain cellular integrity in response to stress. The sirtuin family, a group of NAD-dependent deacetylases, has been the focus of much attention in recent years for their multiple regulatory functions, especially in aging and metabolism. Recent reports validated the significant link between mitochondrial stress responses and the sirtuin family, which may help to elucidate the pathogenesis and therapies for diseases such as Alzheimer's disease or Parkinson's disease. This review will summarize recent related studies and illuminate the interplay between sirtuins and mitochondrial stress.
线粒体通过提供 ATP 并参与多种过程和信号通路，在保证细胞正常生理功能方面发挥着重要作用。最近，越来越多的研究揭示了线粒体在应对衰老过程、代谢紊乱和神经退行性疾病中的应激源方面的重要作用。线粒体应激反应，包括线粒体未折叠蛋白反应 (UPR)、抗氧化防御、线粒体分裂、线粒体融合和自噬，被诱导以维持细胞完整性以应对应激。近年来，Sirtuin 家族作为一组 NAD 依赖性去乙酰化酶，因其多种调节功能而备受关注，尤其是在衰老和代谢方面。最近的报道证实了线粒体应激反应与 Sirtuin 家族之间的重要联系，这可能有助于阐明阿尔茨海默病或帕金森病等疾病的发病机制和治疗方法。本文将总结最近的相关研究，并阐明 Sirtuins 与线粒体应激之间的相互作用。
