乳香酮 A 和 B，来自乳香树脂的两种倍半萜二聚体。
Commiphoratones A and B, Two Sesquiterpene Dimers from Resina Commiphora.
机构信息
Guangdong Key Laboratory for Genome Stability & Disease Prevention, School of Pharmaceutical Sciences , Shenzhen University Health Science Center , Shenzhen 518060 , China.
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany , Chinese Academy of Sciences , Kunming 650201 , China.
出版信息
Org Lett. 2018 Apr 20;20(8):2220-2223. doi: 10.1021/acs.orglett.8b00561. Epub 2018 Mar 27.
Two sesquiterpene dimers, commiphoratones A (1) and B (2), were isolated from Resina Commiphora. Their structures were elucidated by spectroscopic, computational, and crystallographic methods. Compounds 1 and 2 represent an unusual pattern of dimerization between two types of sesquiterpenes. Moreover, compound 1 has a saddle shape. The plausible biosynthetic pathway for 1 and 2 is presented. Bioassay showed that 1 and 2 significantly block lipid metabolism in a concentration-dependent manner.
从 Commiphora 树脂中分离得到两个倍半萜二聚体，commiphoratones A（1）和 B（2）。通过光谱、计算和晶体学方法阐明了它们的结构。化合物 1 和 2 代表了两种类型的倍半萜之间不寻常的二聚模式。此外，化合物 1 具有鞍形结构。提出了 1 和 2 的可能生物合成途径。生物测定表明，1 和 2 以浓度依赖的方式显著阻断脂质代谢。
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