State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201, PR China.
Guangdong Pharmaceutical University , Guangzhou 510006, PR China.
Org Lett. 2017 Jan 6;19(1):286-289. doi: 10.1021/acs.orglett.6b03661. Epub 2016 Dec 28.
Commiphoranes A-D (1-4), four novel aromatic terpenoids with unprecedented carbon skeletons, were isolated from Resina Commiphora. Their structures were identified by spectroscopic and crystallographic methods. Compounds 1 and 2 are dinorditerpenoids characteristic of a 6/6/6/6 ring system. In contrast, compounds 3 and 4 are sesquiterpenoids possessing a 5/6/7 backbone. Biological evaluation reveals that 3 could significantly attenuate overproduction of fibronectin, collagen I, and α-SMA in TGF-β1-induced rat renal proximal tubular cells.
从 Commiphora 树脂中分离得到了 Commiphoranes A-D（1-4），这是四种具有全新碳骨架的新型芳香萜类化合物。通过光谱和晶体学方法确定了它们的结构。化合物 1 和 2 是具有 6/6/6/6 环系统特征的二萜类化合物。相比之下，化合物 3 和 4 是具有 5/6/7 骨架的倍半萜类化合物。生物评价表明，3 可显著减轻 TGF-β1 诱导的大鼠肾近端肾小管细胞中纤维连接蛋白、胶原 I 和 α-SMA 的过度产生。
