Monayar H K, Ledesma A, Nobile V, Viarengo J A
Venereal Disease Division, Public Health Ministry, Córdoba, Argentina.
Genitourin Med. 1987 Aug;63(4):246-9. doi: 10.1136/sti.63.4.246.
The official records of uncomplicated gonorrhoea for Córdoba state show that between 1975 and 1985, about one in 1000 sexually active people acquired gonorrhoea each year. A study was therefore undertaken to obtain information about treatment of uncomplicated gonorrhoea, as well as the nutritional requirements, plasmid analyses, and susceptibility profiles of gonococci in this geographical area. From August 1983 to April 1984, 219 men with uncomplicated gonorrhoea were treated with one of four antibiotic schedules, all of which were over 95% efficient. All 98 strains isolated and purified were non-penicillinase-producing Neisseria gonorrhoeae (non-PPNG). The minimum inhibitory concentrations (MICs) of benzylpenicillin, tetracycline, thiamphenicol, spectinomycin, kanamycin, and cefoxitin were assessed. The MIC of benzylpenicillin showed that 88% (86) of the strains were inhibited by 0.5 mg/l of the drug, and also showed a bimodal sensitivity pattern to that antibiotic. The nutritional requirements of the 62 strains tested showed that 53% (33) were of the non-requiring (wild type) auxotype, 42% (26) required proline (pro-) and 5% (3) required proline and arginine (pro- arg-). Resistance to antibiotics was more notable in the pro- than in the wild type strains.
科尔多瓦州单纯性淋病的官方记录显示，在1975年至1985年期间，每年每1000名性活跃人群中约有1人感染淋病。因此，开展了一项研究，以获取有关单纯性淋病治疗的信息，以及该地理区域淋球菌的营养需求、质粒分析和药敏谱。1983年8月至1984年4月，219名单纯性淋病男性患者接受了四种抗生素治疗方案中的一种，所有方案的有效率均超过95%。分离并纯化的所有98株菌株均为非产青霉素酶淋病奈瑟菌（非PPNG）。评估了苄青霉素、四环素、甲砜霉素、壮观霉素、卡那霉素和头孢西丁的最低抑菌浓度（MIC）。苄青霉素的MIC显示，88%（86株）的菌株被0.5mg/l的该药物抑制，并且对该抗生素呈现双峰敏感性模式。对62株受试菌株的营养需求研究表明，53%（33株）为非需求型（野生型）营养型，42%（26株）需要脯氨酸（pro-），5%（3株）需要脯氨酸和精氨酸（pro-arg-）。pro-型菌株比野生型菌株对抗生素的耐药性更显著。
