van Klingeren B, Ansink-Schipper M C, Dessens-Kroon M, Verheuvel M
J Antimicrob Chemother. 1985 Aug;16(2):143-7. doi: 10.1093/jac/16.2.143.
The relationship between auxotype, plasmid pattern and susceptibility to antibiotics has been studied in 2396 penicillinase-producing Neisseria gonorrhoeae isolated in The Netherlands during 1982 and 1983. The most prevalent auxotypes were proline requiring (Pro-; 44%) and non-requiring with inhibition by phenylalanine (NR Pheni; 39%). The majority (97%) of the Pro- strains carried the 4.5 Mdal resistance plasmid and 99% of the prototrophic strains the 3.2 Mdal plasmid. MICs were determined for cefuroxime, cefotaxime, erythromycin, tetracycline, thiamphenicol and sulphamethoxazole. Pro- isolates were usually less susceptible to antibiotics than prototrophic strains. Evidence was obtained that the level of relative resistance is related to the nutritional requirement as well as the plasmid type.
1982年至1983年期间，在荷兰分离出2396株产青霉素酶淋病奈瑟菌，对其营养缺陷型、质粒图谱与抗生素敏感性之间的关系进行了研究。最常见的营养缺陷型是脯氨酸需求型（Pro-；44%）和苯丙氨酸抑制的非需求型（NR Pheni；39%）。大多数（97%）Pro-菌株携带4.5Mdal耐药质粒，99%的原养型菌株携带3.2Mdal质粒。测定了头孢呋辛、头孢噻肟、红霉素、四环素、甲砜霉素和磺胺甲恶唑的最低抑菌浓度。Pro-分离株通常比原养型菌株对抗生素的敏感性更低。有证据表明，相对耐药水平与营养需求以及质粒类型有关。
