Center for Genomic Medicine, Kyoto University Graduate School of Medicine.
Department of Health Informatics.
J Hypertens. 2018 May;36(5):1147-1153. doi: 10.1097/HJH.0000000000001672.
Cardio-ankle vascular index (CAVI) has been increasingly used as an index for arterial stiffness. However, the degree of longitudinal changes and factors affecting these changes in CAVI (ΔCAVI) are largely unknown. The aim of this study was to descriptively clarify factors associated with longitudinal ΔCAVI for the precise use of this index in the assessment of arterial stiffness.
Study participants comprised 9501 community residents (53.1 ± 13.3 years), with 8004 patients included in the longitudinal analysis. CAVI was calculated by the transient time interval of arterial waveform measured at four extremities.
Factors showing a strong association with baseline CAVI (7.38 ± 1.10) included age (β = 0.586), SBP (β = 0.175), and male sex (β = 0.142), whereas BMI showed an inverse association (β = -0.208) (all P < 0.001). During the 1815 ± 135 days follow-up period, CAVI increased by 0.47 ± 0.68. Multivariate analysis identified age (β = 0.508), male sex (β = 0.089), Brinkman index (β = 0.074), and SBP (β = 0.037) as positive determinants, whereas BMI (β = -0.079) and baseline CAVI (β = -0.590) as inverse determinants for ΔCAVI (all P < 0.001). Further data accumulation is needed to determine a reference value of CAVI due to its large population differences.
Several factors were commonly associated with baseline and longitudinal ΔCAVI. These factors should be carefully considered when CAVI is used for the assessment of arterial stiffness.
心血管踝臂指数（CAVI）已被越来越多地用作动脉僵硬度的指标。然而，CAVI 的纵向变化程度及其变化的影响因素（ΔCAVI）在很大程度上仍不清楚。本研究旨在描述性地阐明与 CAVI 纵向 ΔCAVI 相关的因素，以便更精确地使用该指数评估动脉僵硬度。
研究对象包括 9501 名社区居民（53.1±13.3 岁），其中 8004 名患者纳入纵向分析。CAVI 通过测量四肢动脉波形的瞬态时间间隔来计算。
与基线 CAVI（7.38±1.10）密切相关的因素包括年龄（β=0.586）、SBP（β=0.175）和男性（β=0.142），而 BMI 呈负相关（β=-0.208）（均 P<0.001）。在 1815±135 天的随访期间，CAVI 增加了 0.47±0.68。多变量分析确定年龄（β=0.508）、男性（β=0.089）、Brinkman 指数（β=0.074）和 SBP（β=0.037）为正向决定因素，而 BMI（β=-0.079）和基线 CAVI（β=-0.590）为 ΔCAVI 的负向决定因素（均 P<0.001）。由于人口差异较大，需要进一步的数据积累来确定 CAVI 的参考值。
几个因素与基线和纵向 ΔCAVI 密切相关。在使用 CAVI 评估动脉僵硬度时，应仔细考虑这些因素。
