International Centre for Reproductive Health, Ghent University, De Pintelaan 185, 9000, Ghent, Belgium.
The South African Department of Science and Technology-National Research Foundation (DST-NRF) Centre of Excellence in Epidemiological Modelling and Analysis (SACEMA), Stellenbosch University, 19 Jonkershoek Road, Stellenbosch, 7600, South Africa.
BMC Public Health. 2018 Mar 27;18(1):403. doi: 10.1186/s12889-018-5327-7.
Age disparities in sexual relationships have been proposed as a key risk factor for HIV transmission in Sub-Saharan Africa, but evidence remains inconclusive. The SIHR study, a cluster randomised trial of a cash transfer programme in Malawi, found that young women in the intervention groups were less likely to have had a sexual partner aged 25 or older, and less likely to test positive for HIV and HSV-2 at follow-up compared to control groups. We examined the hypotheses that girls in the intervention groups had smaller age differences than control groups and that large age differences were associated with relationship-level HIV transmission risk factors: inconsistent condom use, sex frequency, and relationship duration.
We conducted an analysis of schoolgirls in the Schooling, Income, and Health Risk (SIHR) study aged 13-22 at baseline (n = 2907). We investigated the effects of study arm, trial stage and participant age on age differences in sexual relationships using a linear mixed-effects model. Cumulative-link mixed-effects models were used to estimate the effect of relationship age difference on condom use and sex frequency, and a Cox proportional hazard model was used to estimate the effect of relationship age difference on relationship duration. We controlled for the girl's age, number of partners, study group and study round.
Girls receiving cash transfers, on average, had smaller age differences in relationships compared to controls, though the estimated difference was not statistically significant (- 0.43 years; 95% CI: -1.03, 0.17). The older the participant was, the smaller her age differences (- 0.67 per 4-year increase in age; 95% CI: -0.99, - 0.35). Among controls, after the cash transfers had ended the average age difference was 0.82 years larger than during the intervention (95% CI: 0.43, 1.21), suggesting a possible indirect effect of the study on behaviour in the community as a whole. Across treatment groups, larger age differences in relationships were associated with lower levels of condom use, more frequent sex, and longer relationship durations.
Cash-transfer programmes may prevent HIV transmission in part by encouraging young women to form age-similar relationships, which are characterised by increased condom use and reduced sex frequency. The benefits of these programmes may extend to those who are not directly receiving the cash.
年龄差距较大的性关系被认为是撒哈拉以南非洲地区 HIV 传播的一个关键风险因素,但证据仍不明确。SIHR 研究是马拉维一项关于现金转移计划的集群随机试验,结果发现,与对照组相比,干预组中的年轻女性与年龄较大(25 岁及以上)的性伴侣发生性关系的可能性较低,而且在随访时 HIV 和 HSV-2 的检测呈阳性的可能性也较低。我们检验了以下假设:干预组中的女孩与对照组相比年龄差异较小,而较大的年龄差异与关系层面的 HIV 传播风险因素有关: condom 使用率不一致、性行为频率和关系持续时间。
我们对基线时年龄在 13-22 岁的 SIHR 研究中的女学生进行了一项分析(n=2907)。我们使用线性混合效应模型研究了研究臂、试验阶段和参与者年龄对性关系中年龄差异的影响。累积链接混合效应模型用于估计关系年龄差异对 condom 使用和性行为频率的影响,Cox 比例风险模型用于估计关系年龄差异对关系持续时间的影响。我们控制了女孩的年龄、性伴侣数量、研究组和研究轮次。
接受现金转移的女孩的关系年龄差异平均比对照组小,但估计差异没有统计学意义(-0.43 岁;95%CI:-1.03,0.17)。参与者年龄越大,年龄差异越小(每增加 4 岁,年龄差异减少 0.67 岁;95%CI:-0.99,-0.35)。在对照组中,现金转移结束后,平均年龄差异比干预期间大 0.82 岁(95%CI:0.43,1.21),这表明研究对整个社区行为可能产生了间接影响。在治疗组中,较大的关系年龄差异与 condom 使用频率降低、性行为频率增加和关系持续时间延长有关。
现金转移计划可能通过鼓励年轻女性建立年龄相似的关系来预防 HIV 传播,这种关系的特点是 condom 使用增加和性行为频率降低。这些计划的好处可能会扩展到那些没有直接获得现金的人。