[重症肌无力中的抗乙酰胆碱和抗受体抗体]
[Anti-acetylcholine and anti-receptor antibodies in myasthenia].
作者信息
Lebrun-Grandie P, Souan M L, Geffard M, Dartigues J F, Mauricet B, Orgogozo J M
机构信息
Clinique neurologique, Hôpital Pellegrin, Bordeaux.
出版信息
Presse Med. 1987 Oct 3;16(32):1577-80.
The presence of anti-acetylcholine antibodies has been demonstrated in 24 patients with myasthenia gravis. Their titer was moderately but significantly higher than in controls. There was no significant correlation between the titer of these anti-acetylcholine antibodies and the clinical severity of the disease or the titer of anti-receptor antibodies in the same patients. Several populations of antibodies are present in myasthenia gravis according to an idiotype-anti-idiotype process, reflecting the complexity of immune reactions.
在24例重症肌无力患者中已证实存在抗乙酰胆碱抗体。其滴度中度但显著高于对照组。这些抗乙酰胆碱抗体的滴度与疾病的临床严重程度或同一患者体内抗受体抗体的滴度之间无显著相关性。根据独特型-抗独特型过程，重症肌无力患者体内存在几种抗体群体，这反映了免疫反应的复杂性。
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