Experiment Center, the Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Department of basic surgery, Hebei Medical University, Shijiazhuang, Hebei, China.
Environ Sci Pollut Res Int. 2018 Jun;25(16):15934-15942. doi: 10.1007/s11356-018-1845-1. Epub 2018 Mar 27.
Widespread phthalate exposure has been recently documented and is hypothesized to increase blood pressure (BP) in humans. However, current studies have provided inconclusive evidence for an association between phthalate exposure and BP. Human epidemiologic studies on the topic remain lacking. Therefore, this study aims to examine the association between serum phthalate concentrations and BP in a Chinese population. We measured several parameters of BP (systolic BP, diastolic BP, total cholesterol, and triglyceride) and the concentrations of 16 phthalates (dimethyl phthalate (DMP), diethyl phthalate, diisobutyl phthalate, dibutyl phthalate (DBP), bis (2-methoxyethyl) phthalate, bis (4-methyl-2-pentyl) phthalate, bis (2-ethoxyethyl) phthalate, diamyl phthalate, dihexyl phthalate, benzyl butyl phthalate, bis (2-nbutoxyethyl) phthalate (DBEP), dicyclohexyl phthalate, bis (2-ethyl hexyl) phthalate (DEHP), diisononyl phthalate, diphenyl phthalate, and di-n-octyl phthalate) in the serum of 474 adults recruited from a primary health care clinic. The relationship between serum phthalate concentrations and BP parameters was assessed with multivariate linear regressions. DBP was the most ubiquitous and dominant contaminant in the study population. The systolic BP of subjects in the median-exposure DEHP group significantly increased by 2.96 mmHg (p < 0.05) relative to that of subjects in the low-exposure group. Significant positive dose-related associations of DMP and DBEP with the levels of total cholesterol in serum (p for trend < 0.05) were also found. These associations persisted even when considering exposure to multiple phthalates. Our results suggested that phthalate exposure might increase BP in adults. However, our findings warrant further studies in a larger and more general population.
广泛的邻苯二甲酸酯暴露最近已被记录在案，并被假设会导致人类血压升高。然而，目前的研究并没有提供邻苯二甲酸酯暴露与血压之间存在关联的明确证据。关于这个主题的人类流行病学研究仍然缺乏。因此，本研究旨在研究中国人群中血清邻苯二甲酸酯浓度与血压之间的关系。我们测量了血压的几个参数（收缩压、舒张压、总胆固醇和甘油三酯）和 16 种邻苯二甲酸酯的浓度（邻苯二甲酸二甲酯（DMP）、邻苯二甲酸二乙酯、邻苯二甲酸二异丁酯、邻苯二甲酸二丁酯（DBP）、邻苯二甲酸二（2-甲氧基乙基）酯、邻苯二甲酸二（4-甲基-2-戊基）酯、邻苯二甲酸二（2-乙氧基乙基）酯、邻苯二甲酸二戊酯、邻苯二甲酸二己酯、邻苯二甲酸苄基丁基酯、邻苯二甲酸二（2-正丁氧基乙基）酯（DBEP）、邻苯二甲酸二环己酯、邻苯二甲酸二（2-乙基己基）酯（DEHP）、邻苯二甲酸二异壬酯、邻苯二甲酸二辛酯）在从一家初级保健诊所招募的 474 名成年人的血清中。使用多元线性回归评估血清邻苯二甲酸酯浓度与血压参数之间的关系。DBP 是研究人群中最普遍和占主导地位的污染物。与低暴露组相比，DEHP 中值暴露组的收缩压显着升高 2.96mmHg（p<0.05）。还发现 DMP 和 DBEP 与血清总胆固醇水平呈显著正相关剂量关系（趋势 p<0.05）。即使考虑到多种邻苯二甲酸酯的暴露，这些关联仍然存在。我们的结果表明，邻苯二甲酸酯暴露可能会导致成年人血压升高。然而，我们的发现需要在更大和更一般的人群中进行进一步研究。
