Peng Ming, Yi Ya X, Zhang Tong, Ding Yue, Le Jian
School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Department of Chemistry, Shanghai Institute for Food and Drug Control, Shanghai, China.
Front Pharmacol. 2018 Mar 13;9:188. doi: 10.3389/fphar.2018.00188. eCollection 2018.
(Sanqi), a traditional Chinese medical drug which has been applied to medical use for over four centuries, contains high content of dammarane-type tetracyclic triterpenoid saponins. A number of stereoisomeric dammarane-type saponins exist in this precious herb, and some are particularly regarded as "biomarkers" in processed notoginseng. Contemporary researches have indicated that some saponin stereoisomers may show stereospecific pharmacological activities, such as anti-tumor, antioxidative, anti-photoaging, anti-inflammatory, antidiabetic, and neuro-protective activities, as well as stereoselective effects on ion channel current regulation, cardiovascular system, and immune system. The current review provides a comprehensive overview of chemical compositions of raw and processed with a particular emphasis on saponin stereoisomers. Besides, the pharmacological and pharmacokinetic researches, as well as determination and biotechnological preparation methods of stereoisomeric saponins in notoginseng are discussed extensively.
三七，一种已应用于医学领域四个多世纪的传统中药，含有高含量的达玛烷型四环三萜皂苷。这种珍贵草药中存在多种立体异构的达玛烷型皂苷，其中一些在三七炮制品中被特别视为“生物标志物”。当代研究表明，一些皂苷立体异构体可能表现出立体特异性药理活性，如抗肿瘤、抗氧化、抗光老化、抗炎、抗糖尿病和神经保护活性，以及对离子通道电流调节、心血管系统和免疫系统的立体选择性作用。本综述全面概述了三七生品和炮制品的化学成分，特别强调了皂苷立体异构体。此外，还广泛讨论了三七中立体异构皂苷的药理和药代动力学研究，以及其测定和生物技术制备方法。
